Breastfeeding and Mammographic Breast Density: A Cross-sectional Study.
Breastfeeding and Mammographic Breast Density: A Cross-sectional Study.
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DOI：
10.1158/1940-6207.capr-22-0482
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发表时间：
2023-06-01
影响因子：
3.3
通讯作者：
Toriola, Adetunji T.
中科院分区：
文献类型：
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作者：
Getz, Kayla R.;Adedokun, Babatunde;Xu, Shuai;Toriola, Adetunji T.
母乳喂养与乳腺癌风险呈负相关，但母乳喂养与乳房X线摄影乳腺密度（MBD）的关系尚不清楚。我们调查了母乳喂养与MBD体积测量（体积百分比密度（VPD），致密体积（DV）和非致密体积（NDV））之间的关系，并评估了种族，绝经状态和体重指数（BMI）是否存在差异。研究人群包括964名在密苏里州圣路易斯市华盛顿大学医学院接受筛查性乳房X线摄影的女性（67%非西班牙裔白色，29%非西班牙裔黑人）。对VPD、DV和NDV进行log 10转换。我们进行了多变量线性回归模型调整年龄，体重指数，乳腺癌家族史，种族，初潮年龄在所有参与者和专门在产妇。平均年龄为50.7岁。母乳喂养0-6个月的妇女VPD比未产妇低12%（10^β=0.88，95%CI（0.79，0.98））。母乳喂养与DV呈负相关（经产未母乳喂养：10^β=0.93，95%CI（0.83，1.04），母乳喂养0-6个月：10^β=0.91，95%CI（0.79，1.05），母乳喂养7-12个月：10^β=0.94，95%CI（0.81，1.10），母乳喂养>12个月：10^β=0.87，95%CI（0.78，0.98），p-trend=0.03）。BMI改变了母乳喂养和VPD之间的关联。母乳喂养0-6个月且BMI <25 kg/m2的女性与未经产女性相比，VPD较低，但BMI ≥ 25 kg/m2的女性之间没有相关性（p-交互作用=0.04）。在这个多样化的研究人群中，母乳喂养与VPD的关联似乎受到BMI的影响，而不是种族或绝经状态。未来的研究需要探索母乳喂养与其他乳房X线摄影特征的关联。
Breastfeeding is inversely associated with breast cancer risk but the associations of breastfeeding with mammographic breast density (MBD) are not clear. We investigated the association between breastfeeding and volumetric measures of MBD (volumetric percent density (VPD), dense volume (DV) and non-dense volume (NDV)) and evaluated whether it differs by race, menopausal status, and body mass index (BMI). The study population was comprised of 964 women (67% non-Hispanic white, 29% non-Hispanic black) who had screening mammography at Washington University School of Medicine, St. Louis, MO. VPD, DV and NDV were log10 transformed. We performed multivariable linear regression models adjusted for age, BMI, family history of breast cancer, race, and age at menarche among all participants and exclusively in parous women. Mean age was 50.7 years. VPD was 12% lower among women who breastfed 0–6 months, (10^β=0.88, 95%CI (0.79,0.98)) compared to nulliparous women. Breastfeeding was inversely associated with DV (parous never breastfed: 10^β=0.93, 95%CI (0.83,1.04), breastfed 0–6 months: 10^β=0.91, 95%CI (0.79,1.05), breastfed 7–12 months: 10^β=0.94, 95%CI (0.81,1.10), breastfed >12 months: 10^β=0.87, 95%CI (0.78,0.98), p-trend=0.03). BMI modified the association between breastfeeding and VPD. Women who breastfed for 0–6 months and had a BMI < 25kg/m2 had lower VPD compared to nulliparous women, but among women with a BMI ≥ 25kg/m2 there was no association (p-interaction=0.04). In this diverse study population, the association of breastfeeding with VPD appears to be modified by BMI, but not by race or menopausal status. Future research exploring the associations of breastfeeding with other mammographic features are needed.
DOI：
10.1007/s10552-011-9733-8
发表时间：
2011-04
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Tehranifar P;Reynolds D;Flom J;Fulton L;Liao Y;Kudadjie-Gyamfi E;Terry MB
通讯作者：
Terry MB
了解中国乳房X线乳房密度的特征：使用癌症筛查计划中的现实世界数据对乳房密度进行中澳大利亚的比较研究。
影响因子：
1.9
作者：
Li, Tong;Li, Jing;Heard, Rob;Gandomkar, Ziba;Ren, Jiansong;Dai, Min;Brennan, Patrick
通讯作者：
Brennan, Patrick