Reproductive and menstrual factors and mammographic density in African American, Caribbean, and white women.
Reproductive and menstrual factors and mammographic density in African American, Caribbean, and white women.
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DOI：
10.1007/s10552-011-9733-8
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Terry MB
中科院分区：
文献类型：
--
作者：
Tehranifar P;Reynolds D;Flom J;Fulton L;Liao Y;Kudadjie-Gyamfi E;Terry MB
在以少数民族和移民为主的样本中，我们调查了乳腺癌的生殖和月经危险因素与乳房摄影密度之间的关系，乳房摄影密度是乳腺癌的一个重要危险因素。我们采访了在乳房X光检查预约期间(n=191，平均年龄=50)没有乳腺癌病史的女性(42%非裔美国人，22%非洲加勒比人，22%白人，9%西班牙裔加勒比人，5%其他人)。我们使用了一种计算机辅助的方法来测量头尾乳房X光片中致密乳房组织的面积和百分比。我们使用多变量线性回归分析来估计生殖和月经危险因素与乳房X光摄影密度之间的关系。年龄与密度百分比和致密面积呈负相关，体重指数(BMI)与密度百分比呈负相关。调整年龄、体重指数、种族和绝经状况、月经初潮年龄较晚(例如，β=−7.37，95%CI：−12.29，−2.46，年龄≥13岁与≤11岁)，以及任何激素节育方法的使用(β=−5.10，95%CI：−9.37，−0.84)与致密区域减少相关。种族和出生地(外国出生的和美国出生的)与密度没有直接联系，尽管几个危险因素在种族和出生地群体中的分布存在差异。乳房X光照相密度的平均水平在不同种族和原住民群体中没有差异，但少数民族和移民女性中乳腺癌的几个风险因素与密度有关。
We investigated the associations between reproductive and menstrual risk factors for breast cancer and mammographic density, a strong risk factor for breast cancer, in a predominantly ethnic minority and immigrant sample. We interviewed women (42% African American, 22% African Caribbean, 22% White, 9% Hispanic Caribbean, 5% other) without a history of breast cancer during their mammography appointment (n = 191, mean age = 50). We used a computer-assisted method to measure the area and percentage of dense breast tissue from cranio-caudal mammograms. We used multivariable linear regression analyses to estimate the associations between reproductive and menstrual risk factors and mammographic density. Age was inversely associated with percent density and dense area, and body mass index (BMI) was inversely associated with percent density. Adjusting for age, BMI, ethnicity and menopausal status, later age at menarche (e.g., β = −7.37, 95% CI: −12.29, −2.46 for age ≥13 years vs. ≤ 11 years), and any use of hormonal birth control (HBC) methods (β = −5.10, 95% CI: −9.37, −0.84) were associated with reduced dense area. Ethnicity and nativity (foreign- vs. US-born) were not directly associated with density despite variations in the distribution of several risk factors across ethnic and nativity groups. The mean level of mammographic density did not differ across ethnic and nativity groups, but several risk factors for breast cancer were associated with density in ethnic minority and immigrant women.
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影响因子：
5.6
作者：
El-Bastawissi, AY;White, E;Taplin, S
通讯作者：
Taplin, S
DOI：
10.1097/gme.0b013e3181405b8a
发表时间：
2008-03-01
影响因子：
2.7
作者：
Caire-Juvera, Graciela;Arendell, Leslie A.;Chen, Zhao
通讯作者：
Chen, Zhao
DOI：
10.1038/oby.2004.208
发表时间：
2004-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Consedine, NS;Magai, C;Neugut, AI
通讯作者：
Neugut, AI
DOI：
10.1093/jnci/87.9.670
发表时间：
1995-05-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BOYD, NF;BYNG, JW;YAFFE, MJ
通讯作者：
YAFFE, MJ
影响因子：
3.8
作者：
Li, T;Sun, LM;Boyd, N
通讯作者：
Boyd, N