Regularization mechanisms of spiking-bursting neurons
Regularization mechanisms of spiking-bursting neurons
复制标题
尖峰爆发神经元的正则化机制
DOI：
10.1016/s0893-6080(01)00046-6
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Rabinovich
中科院分区：
文献类型：
--
作者：
P. Varona;J. Torres;R. Huerta;H. Abarbanel;M. Rabinovich
在观察到中央模式发生器（CPG）的单个神经元中的高度可变的爆发活动后，提出了一个重要的问题，即这些细胞的组装如何协同作用以向运动系统产生规则的信号。众所周知，龙虾胃神经节中的一些神经元在与CPG中的任何连接突触隔离时具有高度不规则的尖峰爆发行为。实验记录表明，对单个神经元的周期性刺激可以调节其放电活动。其他证据表明，神经元之间的特定化学和/或电突触也诱导节律的规则化。在本文中，我们提出了一个建模研究中，一个缓慢的亚细胞动力学，细胞内存储和细胞质之间的钙离子交换，是负责的起源和控制的不规则的尖峰爆发活动。我们在周期性驱动下的单细胞模拟和合作活动可以诱导正则化的最小网络中证明了这一点。虽然经常被忽视的现实神经元模型的描述，亚细胞的慢动力学过程可能发挥重要作用的信息处理和短期记忆的发放-爆发神经元。
An essential question raised after the observation of highly variable bursting activity in individual neurons of Central Pattern Generators (CPGs) is how an assembly of such cells can cooperatively act to produce regular signals to motor systems. It is well known that some neurons in the lobster stomatogastric ganglion have a highly irregular spiking–bursting behavior when they are synaptically isolated from any connection in the CPG. Experimental recordings show that periodic stimuli on a single neuron can regulate its firing activity. Other evidence demonstrates that specific chemical and/or electrical synapses among neurons also induce the regularization of the rhythms. In this paper we present a modeling study in which a slow subcellular dynamics, the exchange of calcium between an intracellular store and the cytoplasm, is responsible for the origin and control of the irregular spiking–bursting activity. We show this in simulations of single cells under periodic driving and in minimal networks where the cooperative activity can induce regularization. While often neglected in the description of realistic neuron models, subcellular processes with slow dynamics may play an important role in information processing and short-term memory of spiking–bursting neurons.
影响因子：
15.9
作者：
SHARP, AA;ONEIL, MB;MARDER, E
通讯作者：
MARDER, E