Retinoic acid signaling pathways in development and diseases.
Retinoic acid signaling pathways in development and diseases.
复制标题
DOI：
10.1016/j.bmc.2013.11.025
复制
发表时间：
2014-01-15
影响因子：
3.5
通讯作者：
Evans T
中科院分区：
文献类型：
--
作者：
Das BC;Thapa P;Karki R;Das S;Mahapatra S;Liu TC;Torregroza I;Wallace DP;Kambhampati S;Van Veldhuizen P;Verma A;Ray SK;Evans T
类视黄醇包含一组化合物，每个化合物由三个基本部分组成：作为大疏水基团的三甲基化环己烯环、作为连接单元的共轭四烯侧链和极性碳氧官能团。类胡萝卜素或其他类视黄醇向视黄酸 (RA) 的生化转化对于包括发育、分化、增殖和凋亡在内的多种生物过程的正常调节至关重要。类视黄醇通过与称为视黄酸受体 (RAR) 和类视黄醇 X 受体 (RXR) 的核受体结合来调节各种生理输出，这些受体本身就是 DNA 结合转录调节因子。 RA 及其受体的功能反应受到许多共激活剂和辅阻遏物的调节。类维生素A对于多种器官系统的发育和功能至关重要；然而，类维生素A信号传导失调可能导致严重疾病。几种天然和合成的类维生素A正在临床使用或正在进行治疗包括癌症在内的特定疾病的试验。在这篇综述中，我们对类维生素A在发育和各种疾病中的重要性进行了广泛的概述，重点介绍了药物发现过程中的各种类维生素A，从类维生素A化学到临床应用和成像。
Retinoids comprise a group of compounds each composed of three basic parts: a trimethylated cyclohexene ring that is a bulky hydrophobic group, a conjugated tetraene side chain that functions as a linker unit, and a polar carbon-oxygen functional group. Biochemical conversion of carotenoid or other retinoids to retinoic acid (RA) is essential for normal regulation of a wide range of biological processes including development, differentiation, proliferation, and apoptosis. Retinoids regulate various physiological outputs by binding to nuclear receptors called retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which themselves are DNA-binding transcriptional regulators. The functional response of RA and their receptors are modulated by a host of coactivators and corepressors. Retinoids are essential in the development and function of several organ systems; however, deregulated retinoid signaling can contribute to serious diseases. Several natural and synthetic retinoids are in clinical use or undergoing trials for treating specific diseases including cancer. In this review, we provide a broad overview on the importance of retinoids in development and various diseases, highlighting various retinoids in the drug discovery process, ranging all the way from retinoid chemistry to clinical uses and imaging.
登录
查看更多内容
影响因子：
56.9
作者：
BLOMHOFF, R;GREEN, MH;NORUM, KR
通讯作者：
NORUM, KR
影响因子：
7.3
作者：
Beard, RL;Colon, DF;Chandraratna, RAS
通讯作者：
Chandraratna, RAS
影响因子：
5.3
作者：
Berry, Daniel C.;Noy, Noa
通讯作者：
Noy, Noa
影响因子：
5.3
作者：
Ding, Yun;Qiao, Aimin;Fan, Guo-Huang
通讯作者：
Fan, Guo-Huang
影响因子：
5.3
作者：
Berry, Daniel C.;O'Byrne, Sheila M.;Noy, Noa
通讯作者：
Noy, Noa