Streptavidin-conjugated CdSe/ZnS quantum dots impaired synaptic plasticity and spatial memory process
Streptavidin-conjugated CdSe/ZnS quantum dots impaired synaptic plasticity and spatial memory process
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链霉亲和素共轭 CdSe/ZnS 量子点损害突触可塑性和空间记忆过程
DOI：
10.1007/s11051-013-1575-8
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发表时间：
2013-03
影响因子：
2.5
通讯作者：
Wang, Ming
中科院分区：
文献类型：
--
作者：
Chen, Jutao;Ruan, Di-yun;Chen, Lin;Wang, Ming
研究表明，量子点作为一种新型探针，在体内成像方面展现出广阔的前景，但也表现出潜在的毒性。本研究主要是在大鼠突触可塑性和空间记忆模型中研究量子点暴露后在中枢神经系统（CNS）中的体内反应。将成年大鼠暴露于链霉亲和素缀合的CdSe/ZnS QD（Qdots 525，购自Molecular Probes Inc.）腹腔注射7天，然后进行行为学、电生理学和生化检查。电生理结果显示，QDs损伤后，海马的输入/输出（I/O）功能增强，双脉冲反应和长时程增强（LTP）峰降低，提示突触传递增强，突触可塑性受损。同时，行为学实验也证实了量子点对大鼠空间记忆过程的影响。所有结果均表明量子点损伤可干扰大鼠海马齿状回区突触传递和可塑性，并提示量子点应用中应考虑的潜在不良问题。
Studies reported that quantum dots (QDs), as a novel probe, demonstrated a promising future for in vivo imaging, but also showed potential toxicity. This study is mainly to investigate in vivo response in the central nervous system (CNS) after exposure to QDs in a rat model of synaptic plasticity and spatial memory. Adult rats were exposed to streptavidin-conjugated CdSe/ZnS QDs (Qdots 525, purchased from Molecular Probes Inc.) by intraperitoneal injection for 7 days, followed by behavioral, electrophysiological, and biochemical examinations. The electrophysiological results show that input/output (I/O) functions were increased, while the peak of paired-pulse reaction and long-term potentiation were decreased after QDs insult, indicating synaptic transmission was enhanced and synaptic plasticity in the hippocampus was impaired. Meanwhile, behavioral experiments provide the evidence that QDs could impair rats’ spatial memory process. All the results present evidences of interference of synaptic transmission and plasticity in rat hippocampal dentate gyrus area by QDs insult and suggest potential adverse issues which should be considered in QDs applications.
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10.4
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