Bringing pharmacomicrobiomics to the clinic through well-designed studies.
Bringing pharmacomicrobiomics to the clinic through well-designed studies.
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DOI：
10.1111/cts.13381
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发表时间：
2022-10
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
药物微生物组学研究研究药物与微生物组的相互作用，例如微生物变异对药物反应和处置的影响。研究和理解肠道微生物组与药物之间的相互作用与临床实践变得越来越相关，因为它具有避免药物不良反应或预测药物反应变异性的潜力。人类微生物组的高度可变性给评估微生物的影响带来了重大挑战。旨在探索药物与微生物组相互作用的研究应该经过精心设计，以解释微生物组随时间的变化，并收集饮食、疾病、伴随药物和其他环境因素等混杂因素的数据。在这里，我们针对在人体中进行药物微生物组学研究所需的方法学特征收集了一系列重要的考虑因素和建议，重点关注肠道微生物组。考虑这些因素可以实现特定药物与微生物组之间关系的发现、重现性和更准确的表征。此外，对精心设计的研究结果的适当解释和传播将推动该领域更接近临床相关性和实施。
Pharmacomicrobiomic studies investigate drug‐microbiome interactions, such as the effect of microbial variation on drug response and disposition. Studying and understanding the interactions between the gut microbiome and drugs is becoming increasingly relevant to clinical practice due to its potential for avoiding adverse drug reactions or predicting variability in drug response. The highly variable nature of the human microbiome presents significant challenges to assessing microbes’ influence. Studies aiming to explore drug‐microbiome interactions should be well‐designed to account for variation in the microbiome over time and collect data on confounders such as diet, disease, concomitant drugs, and other environmental factors. Here, we assemble a set of important considerations and recommendations for the methodological features required for performing a pharmacomicrobiomic study in humans with a focus on the gut microbiome. Consideration of these factors enable discovery, reproducibility, and more accurate characterization of the relationships between a given drug and the microbiome. Furthermore, appropriate interpretation and dissemination of results from well‐designed studies will push the field closer to clinical relevance and implementation.
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影响因子：
4.6
作者：
Anderson EL;Li W;Klitgord N;Highlander SK;Dayrit M;Seguritan V;Yooseph S;Biggs W;Venter JC;Nelson KE;Jones MB
通讯作者：
Jones MB
影响因子：
4.6
作者：
Choo JM;Leong LE;Rogers GB
通讯作者：
Rogers GB
影响因子：
13.3
作者：
Artacho, Alejandro;Isaac, Sandrine;Scher, Jose U.
通讯作者：
Scher, Jose U.
影响因子：
5.2
作者：
Bellali, Sara;Lagier, Jean-Christophe;Khalil, Jacques Bou
通讯作者：
Khalil, Jacques Bou
DOI：
10.1056/nejmoa2023294
发表时间：
2021-04-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Chen RY;Mostafa I;Hibberd MC;Das S;Mahfuz M;Naila NN;Islam MM;Huq S;Alam MA;Zaman MU;Raman AS;Webber D;Zhou C;Sundaresan V;Ahsan K;Meier MF;Barratt MJ;Ahmed T;Gordon JI
通讯作者：
Gordon JI