Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment.
Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment.
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DOI：
10.1016/j.neuron.2017.12.039
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发表时间：
2018-02-07
期刊：
影响因子：
16.2
通讯作者：
Salzer JL
中科院分区：
文献类型：
--
作者：
Berger SL;Leo-Macias A;Yuen S;Khatri L;Pfennig S;Zhang Y;Agullo-Pascual E;Caillol G;Zhu MS;Rothenberg E;Melendez-Vasquez CV;Delmar M;Leterrier C;Salzer JL
The axon initial segment (AIS) is the site of action potential generation and a locus of activity-dependent homeostatic plasticity. A multimeric complex of sodium channels, linked via a cytoskeletal scaffold of ankyrin G and beta IV spectrin to submembranous actin rings, mediates these functions. The mechanisms that specify the AIS complex to the proximal axon and underlie its plasticity remain poorly understood. Here we show phosphorylated myosin light chain (pMLC), an activator of contractile myosin II, is highly enriched in the assembling and mature AIS, where it associates with actin rings. MLC phosphorylation and myosin II contractile activity are required for AIS assembly and regulate the distribution of AIS components along the axon. pMLC is rapidly lost during depolarization, destabilizing actin and thereby providing a mechanism for activity-dependent structural plasticity of the AIS. Together, these results identify pMLC/myosin II activity as a common link between AIS assembly and plasticity. Berger et al demonstrate that MLC, a key regulator of contractile myosin II, is enriched in the axon initial segment (AIS) and is associated with actin rings. They show MLC/myosin II have major roles in AIS assembly and activity dependent-plasticity.
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影响因子：
3.3
作者：
Henson JH;Ditzler CE;Germain A;Irwin PM;Vogt ET;Yang S;Wu X;Shuster CB
通讯作者：
Shuster CB
肌动蛋白II活性是轴突初始段处的结构可塑性所必需的。
DOI：
10.1111/ejn.13597
发表时间：
2017-07
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Evans MD;Tufo C;Dumitrescu AS;Grubb MS
通讯作者：
Grubb MS
影响因子：
4.6
作者：
D'Este E;Kamin D;Velte C;Göttfert F;Simons M;Hell SW
通讯作者：
Hell SW
影响因子：
3
作者：
Flynn, Kevin C.;Pak, Chi W.;Shaw, Alisa E.;Bradke, Frank;Bamburg, James R.
通讯作者：
Bamburg, James R.
影响因子：
64.5
作者：
Galiano MR;Jha S;Ho TS;Zhang C;Ogawa Y;Chang KJ;Stankewich MC;Mohler PJ;Rasband MN
通讯作者：
Rasband MN