Immunological defense of CNS barriers against infections.
Immunological defense of CNS barriers against infections.
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DOI：
10.1016/j.immuni.2022.04.012
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发表时间：
2022-05-10
期刊：
影响因子：
32.4
通讯作者：
McGavern, Dorian B.
中科院分区：
文献类型：
--
作者：
Ampie, Leonel;McGavern, Dorian B.
具有物理、化学和免疫学特性的神经解剖屏障在防止外周感染扩散到中枢神经系统中发挥着重要作用。未能将病原体控制在这些屏障内可能会导致非常严重的中枢神经系统疾病。中枢神经系统屏障由一个精心设计的先天和适应性免疫细胞组成，这些细胞对环境挑战高度反应。中枢神经系统及其屏障也可以被先前感染或疫苗接种所引发的记忆T和B细胞保护。在这里，我们从发育、解剖学和免疫学的角度讨论不同的中枢神经系统屏障，并总结我们目前对记忆细胞如何保护中枢神经系统隔区的理解。然后，我们讨论了当代对中枢神经系统屏障系统的挑战(SARS-CoV-2感染)，并强调了通过接种疫苗促进中枢神经系统免疫保护的方法。神经解剖屏障由免疫系统防御，以保护中枢神经系统的实质免受病原体的侵袭。安培和麦加弗恩回顾了中枢神经系统屏障的解剖和发展，以及它们在稳态和对感染的反应中的免疫成分。他们还探讨了如何通过接种疫苗来保护这些屏障，然后讨论了当代中枢神经系统挑战(即SARS-CoV-2)的免疫学和神经发病机制。
Neuroanatomical barriers with physical, chemical, and immunological properties play an essential role in preventing the spread of peripheral infections into the CNS. A failure to contain pathogens within these barriers can result in very serious CNS diseases. CNS barriers are inhabited by an elaborate conglomerate of innate and adaptive immune cells that are highly responsive to environmental challenges. The CNS and its barriers can also be protected by memory T and B cells elicited by prior infection or vaccination. Here, we discuss the different CNS barriers from a developmental, anatomical, and immunological standpoint and summarize our current understanding of how memory cells protect the CNS compartment. We then discuss a contemporary challenge to CNS-barrier system (SARS-CoV-2 infection) and highlight approaches to promote immunological protection of the CNS via vaccination. Neuroanatomical barriers are defended by the immune system to safeguard the CNS parenchyma from pathogens. Ampie and McGavern review the anatomy and development of CNS barriers as well as their immunological composition during steady state and in response to infections. They also explore how to protect these barriers via vaccination and then discuss the immunology and neuropathogenesis of a contemporary CNS challenge (i.e., SARS-CoV-2).
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发表时间：
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期刊：
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