Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009: a longitudinal study.
Mortality attributable to seasonal influenza A and B infections in Thailand, 2005-2009: a longitudinal study.
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DOI：
10.1093/aje/kwu360
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发表时间：
2015-06-01
影响因子：
5
通讯作者：
Meeyai A
中科院分区：
文献类型：
--
作者：
Cooper BS;Kotirum S;Kulpeng W;Praditsitthikorn N;Chittaganpitch M;Limmathurotsakul D;Day NP;Coker R;Teerawattananon Y;Meeyai A
热带和温带地区的流感流行病学有很大不同，但缺乏对热带发展中国家季节性流感死亡率的估计。我们的目标是量化泰国的季节性流感死亡率，泰国是一个热带中等收入国家。2005年至2009年期间聚合酶链式反应确诊的流感感染的时间序列是根据哨点监测网络构建的。这些数据与流感样疾病数据相结合，通过使用贝叶斯回归框架得出流感活动和与死亡率的关系的衡量标准。我们估计每年每100,000人中有6.1人(95%可信区间：0.5，12.4)死于甲型和乙型流感，主要是在60岁的人群中，甲型H1N1流感在4年中有3年是最大的。对于甲型H3N1流感，流感活动和死亡率之间的关系随着时间的推移而变化。流感与因呼吸系统疾病(阳性关联的后验概率为99.8%)、癌症(98.6%)、肾脏疾病(98.0%)和肝病(99.2%)引起的死亡增加有关。未发现与循环系统疾病死亡率有关。在泰国，季节性流感感染与大量死亡率有关，但缺乏在温带国家报告的流感活动与循环系统疾病死亡率之间存在密切关系的证据。
Influenza epidemiology differs substantially in tropical and temperate zones, but estimates of seasonal influenza mortality in developing countries in the tropics are lacking. We aimed to quantify mortality due to seasonal influenza in Thailand, a tropical middle-income country. Time series of polymerase chain reaction–confirmed influenza infections between 2005 and 2009 were constructed from a sentinel surveillance network. These were combined with influenza-like illness data to derive measures of influenza activity and relationships to mortality by using a Bayesian regression framework. We estimated 6.1 (95% credible interval: 0.5, 12.4) annual deaths per 100,000 population attributable to influenza A and B, predominantly in those aged ≥60 years, with the largest contribution from influenza A(H1N1) in 3 out of 4 years. For A(H3N2), the relationship between influenza activity and mortality varied over time. Influenza was associated with increases in deaths classified as resulting from respiratory disease (posterior probability of positive association, 99.8%), cancer (98.6%), renal disease (98.0%), and liver disease (99.2%). No association with circulatory disease mortality was found. Seasonal influenza infections are associated with substantial mortality in Thailand, but evidence for the strong relationship between influenza activity and circulatory disease mortality reported in temperate countries is lacking.
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影响因子：
11.8
作者：
Chow A;Ma S;Ling AE;Chew SK
通讯作者：
Chew SK
影响因子：
5
作者：
Alonso, Wladimir J.;Viboud, Cecile;Miller, Mark A.
通讯作者：
Miller, Mark A.
影响因子：
5.7
作者：
Eilers, PHC;Marx, BD
通讯作者：
Marx, BD
泰国流感病毒：7年的前哨监视数据，2004 - 2010年。
影响因子：
4.4
作者：
Chittaganpitch M;Supawat K;Olsen SJ;Waicharoen S;Patthamadilok S;Yingyong T;Brammer L;Epperson SP;Akrasewi P;Sawanpanyalert P
通讯作者：
Sawanpanyalert P
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H