Asbestos-induced pleural fibrosis and impaired lung function.
Asbestos-induced pleural fibrosis and impaired lung function.
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石棉引起的胸膜纤维化和肺功能受损。
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
J. Merchant
中科院分区：
文献类型：
--
作者：
D. A. Schwartz;L. Fuortes;J. Galvin;L. Burmeister;Lynn E. Schmidt;B. Leistikow;F. P. LaMarte;J. Merchant
为了评估石棉引起的胸膜纤维化的临床意义，我们评估了1,211名钣金工人胸膜纤维化的影像学证据与肺量测定值之间的关系。在患有胸膜纤维化的患者（n = 334）中，78%有局限性斑块，22%有累及肋膈角的弥漫性胸膜增厚。发现与胸膜纤维化的存在和类型相关的因素包括年龄增加（p小于0.001），从业年限更长（p小于0.0001），自首次接触石棉以来的年数更多（p <0.0001），吸烟包年数（p小于0.01），以及间质纤维化的存在和程度（p小于0.0001）。在控制了这些潜在的混杂因素（年龄、从业年数、潜伏期、吸烟包年数和ILO灌注分类）后，线性多变量回归模型显示，局限性斑块（p = 0.007）和弥漫性胸膜增厚（p = 0.008）均与FVC下降独立相关，但与FEV 1/FVC比值下降无关。此外，我们的数据表明弥漫性胸膜增厚对FVC下降的影响大约是局限性胸膜斑块的两倍。我们的结论是，石棉暴露工人胸膜纤维化的存在和类型是独立相关的肺功能模式，这是一个潜在的限制性肺功能缺陷的提示。
To assess the clinical significance of asbestos-induced pleural fibrosis, we evaluated the relationship between radiographic evidence of pleural fibrosis and spirometric values in 1,211 sheet metal workers. Of those with pleural fibrosis (n = 334), 78% had circumscribed plaques and 22% had diffuse pleural thickening involving the costophrenic angle. Factors that were found to be associated with the presence and type of pleural fibrosis included increased age (p less than 0.001), more years in the trade (p less than 0.0001), more years since first exposure to asbestos (p less than 0.0001), more pack-years of cigarette smoking (p less than 0.01), and the presence and degree of interstitial fibrosis (p less than 0.0001). After controlling for these potential confounders (age, years in the trade, latency, pack-years of smoking, and ILO profusion category), linear multivariate regression models demonstrated that both circumscribed plaques (p = 0.007) and diffuse pleural thickening (p = 0.008) were independently associated with decrements in FVC but not with decrements in the FEV1/FVC ratio. Furthermore, our data indicate that the effect of diffuse pleural thickening on decrements in FVC is approximately twice as great as that seen with circumscribed pleural plaques. We conclude that the presence and type of pleural fibrosis among asbestos-exposed workers is independently associated with a pattern of spirometry that is suggestive of an underlying restrictive defect in lung function.
DOI：
10.1164/arrd.1983.127.6.725
发表时间：
1983-06
期刊：
The American review of respiratory disease
影响因子：
--
作者：
R. Knudson;M. Lebowitz;C. Holberg;B. Burrows
通讯作者：
R. Knudson;M. Lebowitz;C. Holberg;B. Burrows
石棉相关的胸膜斑块和肺功能。
影响因子：
3.5
作者：
Oliver,LC;Eisen,EA;Greene,R;Sprince,NL
通讯作者：
Sprince,NL