If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
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DOI：
10.18632/aging.100273
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Poroshina TE
中科院分区：
文献类型：
--
作者：
Anisimov VN;Berstein LM;Popovich IG;Zabezhinski MA;Egormin PA;Piskunova TS;Semenchenko AV;Tyndyk ML;Yurova MN;Kovalenko IG;Poroshina TE
高血糖和高胰岛素血症会加速衰老和癌症。二甲双胍等抗糖尿病药物可降低血糖、胰岛素和IGF-1水平。二甲双胍延长小鼠的寿命并预防癌症，尽管其效果因小鼠品系和性别而异。在这里，我们发现，在3个月、9个月或15个月大的时候开始用二甲双胍慢性治疗雌性自发性高血压小鼠，降低了体温，推迟了与年龄相关的动情功能的关闭。令人惊讶的是，二甲双胍并没有影响血清胆固醇、甘油三酯、葡萄糖和胰岛素的水平。3个月龄时开始使用二甲双胍治疗，平均寿命增加14%，最长寿命增加1个月。治疗开始于9个月大，但平均寿命仅增加6%，而从15个月开始治疗并未增加寿命。无瘤小鼠的平均寿命在“最年轻组”中增加了21%，在“中年组”中增加了7%，而在“最老组”中则减少了13%。当在3个月和9个月大时开始，二甲双胍相应地将第一次肿瘤检测延迟22%和25%。因此，在雌性SHR小鼠中，二甲双胍在年轻和中期开始时可延长寿命并延缓肿瘤发生，但在老年时不会。相比之下，在任何年龄段开始服用二甲双胍都可以改善生殖功能。
Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level. Metformin increases lifespan and prevents cancer in mice, although its effects vary, depending on mice strain and gender. Here we showed that chronic treatment of female outbred SHR mice with metformin started at the age of 3, 9 or 15 months decreased body temperature and postponed age-related switch-off of estrous function. Surprisingly, metformin did not affect levels of serum cholesterol, triglycerides, glucose and insulin. Treatment with metformin started at the age of 3 months increased mean life span by 14% and maximum life span by 1 month. The treatment started at the age of 9 months insignificantly increased mean life span by only 6%, whereas the treatment started at the age of 15 months failed to increase life span. The mean life span of tumor-free mice was increased by 21% in ‘the youngest group’, by 7% in ‘middle-aged group’ and in contrast was reduced by 13% in ‘the oldest group’. When started at the age of 3 and 9 months, metformin delayed the first tumor detection by 22% and 25%, correspondingly. Thus, in female SHR mice, metformin increased life span and postponed tumors when started at the young and middle but not at the old age. In contrast, metformin improves reproductive function when started at any age.
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影响因子：
3.9
作者：
Anisimov, VN;Berstein, LM;Franceschi, C
通讯作者：
Franceschi, C
DOI：
10.1093/gerona/glq155
发表时间：
2010-12-01
影响因子：
5.1
作者：
Flurkey, Kevin;Astle, Clinton M.;Harrison, David E.
通讯作者：
Harrison, David E.
DOI：
10.18632/aging.100034
发表时间：
2009-03-28
期刊：
Aging
影响因子：
--
作者：
Blagosklonny MV
通讯作者：
Blagosklonny MV
影响因子：
4.3
作者：
Anisimov, Vladimir N.;Berstein, Lev M.;Semenchenko, Anna V.
通讯作者：
Semenchenko, Anna V.
DOI：
10.18632/aging.100230
发表时间：
2010-11
期刊：
Aging
影响因子：
--
作者：
Anisimov VN
通讯作者：
Anisimov VN