Mucin gene expression in rat airways following infection and irritation.
Mucin gene expression in rat airways following infection and irritation.
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DOI：
10.1016/s0006-291x(05)81373-7
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发表时间：
1991-11-27
影响因子：
3.1
通讯作者：
Basbaum C
中科院分区：
文献类型：
--
作者：
Jany B;Gallup M;Tsuda T;Basbaum C
Airway mucus hypersecretion occurs in response to infection and irritation and poses an important and poorly understood clinical problem. In order to gain insight into its pathogenesis, we have focused on an mRNA encoding the major mucus glycoprotein, mucin. Northern blots showed that mucin mRNA was abundant in the intestine of specific pathogen free rats whereas it was undetectable in the airways of these rats until pathogen-free conditions were suspended and rats acquired Sendai (Parainfluenza I) virus infections. Airway mucin hybridization signals in rats that were both infected with Sendai virus and exposed to SO2were more intense than those in rats with infection alone. These results suggest that pathogen-and irritant-induced hypersecretion may be partly controlled at the level of mucin mRNA.
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影响因子：
158.5
作者：
HOGG, JC;MACKLEM, PT;THURLBECK, WM
通讯作者：
THURLBECK, WM
DOI：
10.1002/path.1700960111
发表时间：
1968-01-01
期刊：
JOURNAL OF PATHOLOGY AND BACTERIOLOGY
影响因子：
--
作者：
LAMB, D;REID, L
通讯作者：
REID, L
影响因子：
15.9
作者：
CHRISTENSEN, TG;KORTHY, AL;HAYES, JA
通讯作者：
HAYES, JA
影响因子：
3.2
作者：
PERINI, JM;MARIANNE, T;MAZZUCA, M
通讯作者：
MAZZUCA, M
DOI：
10.1164/ajrccm/140.2.477
发表时间：
1989-08-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
AIKAWA, T;SHIMURA, S;TAKAHASHI, T
通讯作者：
TAKAHASHI, T