Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM).
Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM).
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中脑上升唤醒网络核的回顾以及对肌脑脊髓炎/慢性疲劳综合征（ME/CFS），海湾战争疾病（GWI）（GWI）和运动后不适（PEM）的影响。
DOI：
10.3390/brainsci12020132
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发表时间：
2022-01-19
期刊：
影响因子：
3.3
通讯作者：
Baraniuk JN
中科院分区：
文献类型：
--
作者：
Baraniuk JN
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）和海湾战争病（GWI）具有运动后不适（PEM）、运动性疲惫或运动后症状加重的共同特征。在为期两天的PEM模型中，在高认知负荷工作记忆任务中，次极量运动诱导背侧中脑激活发生显著变化（华盛顿，2020年）（Baraniuk本期）。对照组无净变化。然而，ME/CFS运动后活动增加，而GWI活动显着减少，表明对运动和病理机制的不同反应。这些数据加上GWI中脑和脑干萎缩的发现启发了对背侧中脑和峡部核的解剖学和生理学的回顾，以推断可能导致疾病发病机制和运动后不适的功能障碍机制。上升唤醒网络的核心被寻址。中脑和峡部核参与威胁评估、意识、注意力、情绪、认知、疼痛、压痛、睡眠、体温调节、光和声音敏感性、直立症状和自主神经功能障碍，并且可能导致ME/CFS和GWI的运动后不适症状。
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS and Gulf War Illness (GWI) share features of post-exertional malaise (PEM), exertional exhaustion, or postexertional symptom exacerbation. In a two-day model of PEM, submaximal exercise induced significant changes in activation of the dorsal midbrain during a high cognitive load working memory task (Washington 2020) (Baraniuk this issue). Controls had no net change. However, ME/CFS had increased activity after exercise, while GWI had significantly reduced activity indicating differential responses to exercise and pathological mechanisms. These data plus findings of the midbrain and brainstem atrophy in GWI inspired a review of the anatomy and physiology of the dorsal midbrain and isthmus nuclei in order to infer dysfunctional mechanisms that may contribute to disease pathogenesis and postexertional malaise. The nuclei of the ascending arousal network were addressed. Midbrain and isthmus nuclei participate in threat assessment, awareness, attention, mood, cognition, pain, tenderness, sleep, thermoregulation, light and sound sensitivity, orthostatic symptoms, and autonomic dysfunction and are likely to contribute to the symptoms of postexertional malaise in ME/CFS and GWI.
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影响因子：
3.8
作者：
Wilson RL;Paterson KB;McGowan V;Hutchinson CV
通讯作者：
Hutchinson CV
影响因子：
4.3
作者：
Rayhan RU;Baraniuk JN
通讯作者：
Baraniuk JN
DOI：
10.1016/j.nicl.2018.07.011
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Barnden LR;Shan ZY;Staines DR;Marshall-Gradisnik S;Finegan K;Ireland T;Bhuta S
通讯作者：
Bhuta S
影响因子：
4.2
作者：
Barnden, Leighton R.;Shan, Zack Y.;Bhuta, Sandeep
通讯作者：
Bhuta, Sandeep
影响因子：
3.4
作者：
Chao, Linda L.;Zhang, Yu;Buckley, Shannon
通讯作者：
Buckley, Shannon