Submaximal Exercise Provokes Increased Activation of the Anterior Default Mode Network During the Resting State as a Biomarker of Postexertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
Submaximal Exercise Provokes Increased Activation of the Anterior Default Mode Network During the Resting State as a Biomarker of Postexertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
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DOI：
10.3389/fnins.2021.748426
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发表时间：
2021
影响因子：
4.3
通讯作者：
Baraniuk JN
中科院分区：
文献类型：
--
作者：
Rayhan RU;Baraniuk JN
背景：肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)以致残疲劳和劳后不适为特征。我们开发了一种激发范式，连续几天进行两次次极量的自行车运动负荷试验，并在运动前后进行磁共振成像、立位耐力和症状评估，以诱导运动性症状恶化和认知功能障碍的客观变化。方法：对34例ME/CFS患者和24例对照组进行运动前、运动后静息状态下的血氧水平依赖(BOLD)扫描。FSL数据库中具有显著粗体信号的种子区域是使用独立分量分析聚集成网络的节点。通过一般线性模型和单因素方差分析确定运动前和运动后两组之间的信号幅度差异。结果：在ME/CFS中，最显著的运动诱导效应是作为默认模式网络(DMN)前节点的内侧前额叶皮质自发活动增加。相反，对于对照组来说，这个区域的激活减少了。总体而言，对照组有更高的粗体信号，表明ME/CFS的全球脑血流量减少。结论：运动后DMN前结节激活的动态增加可能是CFS劳后不适和症状加重的生物标志物。现在可以通过与COVID后疲劳、海湾战争疾病、纤维肌痛、慢性特发性疲劳以及系统性内科和精神疾病中的疲劳进行比较来评估ME/CFS的这种力竭后发现的特异性。
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by disabling fatigue and postexertional malaise. We developed a provocation paradigm with two submaximal bicycle exercise stress tests on consecutive days bracketed by magnetic resonance imaging, orthostatic intolerance, and symptom assessments before and after exercise in order to induce objective changes of exercise induced symptom exacerbation and cognitive dysfunction. Method: Blood oxygenation level dependent (BOLD) scans were performed while at rest on the preexercise and postexercise days in 34 ME/CFS and 24 control subjects. Seed regions from the FSL data library with significant BOLD signals were nodes that clustered into networks using independent component analysis. Differences in signal amplitudes between groups on pre- and post-exercise days were determined by general linear model and ANOVA. Results: The most striking exercise-induced effect in ME/CFS was the increased spontaneous activity in the medial prefrontal cortex that is the anterior node of the Default Mode Network (DMN). In contrast, this region had decreased activation for controls. Overall, controls had higher BOLD signals suggesting reduced global cerebral blood flow in ME/CFS. Conclusion: The dynamic increase in activation of the anterior DMN node after exercise may be a biomarker of postexertional malaise and symptom exacerbation in CFS. The specificity of this postexertional finding in ME/CFS can now be assessed by comparison to post-COVID fatigue, Gulf War Illness, fibromyalgia, chronic idiopathic fatigue, and fatigue in systemic medical and psychiatric diseases.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.4
作者：
Biswal, Bharat;Kunwar, Pratap;Natelson, Benjamin H.
通讯作者：
Natelson, Benjamin H.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.7
作者：
Clarke, Tomas;Jamieson, Jessie D.;Baraniuk, James N.
通讯作者：
Baraniuk, James N.
影响因子：
7.4
作者：
Garner, Richard;Baraniuk, James N.
通讯作者：
Baraniuk, James N.