New focus on alpha-crystallins in retinal neurodegenerative diseases.
New focus on alpha-crystallins in retinal neurodegenerative diseases.
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DOI：
10.1016/j.exer.2010.11.008
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发表时间：
2011-02
影响因子：
3.4
通讯作者：
Lampi, Kirsten J.
中科院分区：
文献类型：
--
作者：
Fort, Patrice E.;Lampi, Kirsten J.
晶状体蛋白最初被鉴定为眼透镜的结构蛋白，并且最近被证明在正常视网膜中表达。它们被大范围的视网膜疾病显著上调，包括糖尿病视网膜病变、年龄相关性黄斑变性、葡萄膜炎、创伤和缺血。晶体蛋白家族由α-、β-和γ-晶体蛋白组成。α-晶体蛋白是一种小的热休克蛋白，最近受到了广泛的关注。本文综述了α-晶体蛋白在视网膜疾病中的作用、其在视网膜神经元细胞存活和视网膜炎症中的作用以及其表达和活性的调节。它们在神经退行性疾病新疗法开发中的潜在作用也进行了讨论。
The crystallin proteins were initially identified as structural proteins of the ocular lens and have been recently demonstrated to be expressed in normal retina. They are dramatically upregulated by a large range of retinal diseases including diabetic retinopathy, age-related macular degeneration, uveitis, trauma and ischemia. The crystallin family of proteins is composed of alpha-, beta- and gamma-crystallin. Alpha-crystallins, which are small heat shock proteins, have received substantial attention recently. This review summarizes the current knowledge of alpha-crystallins in retinal diseases, their roles in retinal neuron cell survival and retinal inflammation, and the regulation of their expression and activity. Their potential role in the development of new treatments for neurodegenerative diseases is also discussed.
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DOI：
10.1006/bbrc.1995.1391
发表时间：
1995-03-17
影响因子：
3.1
作者：
CHERIAN, M;ABRAHAM, EC
通讯作者：
ABRAHAM, EC
影响因子：
3.4
作者：
Lampi, KJ;Ma, ZX;David, LL
通讯作者：
David, LL
影响因子：
3.3
作者：
Gehlbach, P;Hose, S;Sinha, D
通讯作者：
Sinha, D
影响因子：
4.4
作者：
Johnson, PT;Brown, MN;Johnson, LV
通讯作者：
Johnson, LV
影响因子：
3.9
作者：
Kumar, PA;Haseeb, A;Reddy, GB
通讯作者：
Reddy, GB