Does timing of adjuvant chemotherapy influence the prognosis after early breast cancer? Results of the Danish Breast Cancer Cooperative Group (DBCG).
Does timing of adjuvant chemotherapy influence the prognosis after early breast cancer? Results of the Danish Breast Cancer Cooperative Group (DBCG).
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DOI：
10.1038/sj.bjc.6602734
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发表时间：
2005-09-19
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是研究早期乳腺癌术后延迟3个月开始辅助化疗对生存率的影响。在丹麦乳腺癌协作组的全国临床试验中，在1977至1999年间，7501名乳腺癌患者在手术后3个月内接受了化疗：352人接受了经典的环磷酰胺、甲氨蝶呤和5-氟尿嘧啶(CMF)；6065人接受了CMF静脉注射。1084为环磷酰胺、表阿霉素和5-氟尿嘧啶。为了进行分析，将手术到开始化疗的时间分为4个阶段(1-3、4、5和6-13周)。结果表明，在三组化疗中，已知的预后因素在化疗开始的四个层面上分布均匀。没有模式表明早期开始化疗会有好处。对于预后较差的患者亚组(许多患者涉及淋巴结、高级别恶性肿瘤或激素受体阴性疾病)，未发现显著的相互作用。总而言之，我们没有发现任何证据表明在术后2-3个月内早期开始辅助化疗对患者的生存有好处。
The purpose of this study was to examine the effect on survival of delaying the start of adjuvant chemotherapy for early breast cancer for up to 3 months after surgery. In the nation-wide clinical trials of the Danish Breast Cancer Cooperative Group, 7501 breast cancer patients received chemotherapy within 3 months of surgery between 1977 and 1999: 352 with classical cyclofosfamide, metotrexate and 5-fluorouracil (CMF); 6065 with CMF i.v. and 1084 with cyclofosfamide, epirubicin and 5-fluorouracil. For the analysis, the time between surgery and the start of chemotherapy was divided into four strata (1–3, 4, 5 and 6–13 weeks). The results show that within the three groups of chemotherapy, there was an even distribution of known prognostic factors across the four strata of initiation of chemotherapy. There was no pattern indicating a benefit from early start of chemotherapy. No significant interactions were found for subgroups of patients with a poorer prognosis (many involved lymph nodes, high-grade malignancies or hormone receptor negative disease). In conclusion, we have found no evidence for a survival benefit due to early initiation of adjuvant chemotherapy within the first 2–3 months after surgery.
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影响因子：
8.4
作者：
van der Hage, JA;van de Velde, CJH;Duchateau, L
通讯作者：
Duchateau, L
影响因子：
45.3
作者：
Kaufmann, M;von Minckwitz, G;Senn, HJ
通讯作者：
Senn, HJ
影响因子：
45.3
作者：
Shannon, C;Ashley, S;Smith, IE
通讯作者：
Smith, IE
影响因子：
45.3
作者：
Colleoni, M;Bonetti, M;Goldhirsch, A
通讯作者：
Goldhirsch, A
影响因子：
3.1
作者：
ANDERSEN, KW;MOURIDSEN, HT
通讯作者：
MOURIDSEN, HT