Network connectivity of motor control in the ageing brain.
Network connectivity of motor control in the ageing brain.
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DOI：
10.1016/j.nicl.2018.02.001
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Grefkes C
中科院分区：
文献类型：
--
作者：
Michely J;Volz LJ;Hoffstaedter F;Tittgemeyer M;Eickhoff SB;Fink GR;Grefkes C
在运动表现中，老年人通常比年轻人表现出更强的区域大脑活动。然而，关于大脑区域之间运动网络相互作用的年龄相关变化的知识仍然很少。我们在这里调查的影响，在运动选择和启动过程中，使用动态因果模型（DCM）的皮质区的相互作用的老化。我们发现，与年龄相关的心理活动放缓伴随着区域活动和有效连接的增加，特别是针对初级运动皮层（M1）的“核心”运动耦合。有趣的是，老年组中的年轻参与者表现出针对M1的最强连接，随着年龄的增长而稳步下降。相反，前额叶对运动系统的影响随着年龄的增长而增加，并且与顶叶影响和核心运动耦合的减少呈负相关。有趣的是，前额叶-运动前区-M1轴内较高的净耦合预示着衰老过程中更快的心理速度。因此，与年龄相关的统一下降相反，我们的研究结果与不同年龄相关的补偿机制的想法是一致的，前额叶皮层在补偿核心运动网络内耦合减少方面发挥着重要作用。随着年龄的增长，增强的运动网络活动和连接的Parietal-premotor和premotor-M1耦合下降。前额叶对运动系统的影响随着年龄的增长而增加。前额叶皮层弥补了与年龄相关的其他运动联系的下降。前额叶-前运动-M1耦合预测老化中的心理速度。
Older individuals typically display stronger regional brain activity than younger subjects during motor performance. However, knowledge regarding age-related changes of motor network interactions between brain regions remains scarce. We here investigated the impact of ageing on the interaction of cortical areas during movement selection and initiation using dynamic causal modelling (DCM). We found that age-related psychomotor slowing was accompanied by increases in both regional activity and effective connectivity, especially for ‘core’ motor coupling targeting primary motor cortex (M1). Interestingly, younger participants within the older group showed strongest connectivity targeting M1, which steadily decreased with advancing age. Conversely, prefrontal influences on the motor system increased with advancing age, and were inversely correlated with reduced parietal influences and core motor coupling. Interestingly, higher net coupling within the prefrontal-premotor-M1 axis predicted faster psychomotor speed in ageing. Hence, as opposed to a uniform age-related decline, our findings are compatible with the idea of different age-related compensatory mechanisms, with an important role of the prefrontal cortex compensating for reduced coupling within the core motor network. Enhanced motor network activity and connectivity in ageing Parietal-premotor and premotor-M1 coupling decreases with advancing age. Prefrontal influences on the motor system increase with advancing age. Prefrontal cortex compensates for age-related decline in other motor connections. Prefrontal-premotor-M1 coupling predicts psychomotor speed in ageing.
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影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
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作者：
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作者：
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影响因子：
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作者：
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通讯作者：
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