Role of brain inflammation in epileptogenesis.
Role of brain inflammation in epileptogenesis.
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DOI：
10.3349/ymj.2008.49.1.1
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发表时间：
2008-02-29
影响因子：
2.4
通讯作者：
Koh S
中科院分区：
文献类型：
--
作者：
Choi J;Koh S
已知炎症参与越来越多的急性和慢性神经系统疾病的介导。即便如此，炎症参与癫痫和癫痫引起的脑损伤的发病机制只是最近才被认识到。炎症过程，包括小胶质细胞和星形胶质细胞的活化和促炎细胞因子和相关分子的产生，已经在人类癫痫患者以及癫痫的实验模型中描述。几十年来，有效使用抗炎治疗（如类固醇）治疗各种原因的难治性儿科癫痫，暗示了脑炎症的功能作用。相反，常见的儿科感染性或自身免疫性疾病在病程中往往伴有癫痫发作。此外，炎症的遗传易感性与癫痫风险增加相关。因此，越来越多的证据支持这一假设，炎症可能有助于癫痫发生和癫痫引起神经元损伤。我们提供了一个概述，目前的知识，涉及脑炎症作为一个共同的诱发因素，癫痫，特别是儿童癫痫。
Inflammation is known to participate in the mediation of a growing number of acute and chronic neurological disorders. Even so, the involvement of inflammation in the pathogenesis of epilepsy and seizure-induced brain damage has only recently been appreciated. Inflammatory processes, including activation of microglia and astrocytes and production of proinflammatory cytokines and related molecules, have been described in human epilepsy patients as well as in experimental models of epilepsy. For many decades, a functional role for brain inflammation has been implied by the effective use of anti-inflammatory treatments, such as steroids, in treating intractable pediatric epilepsy of diverse causes. Conversely, common pediatric infectious or autoimmune diseases are often accompanied by seizures during the course of illness. In addition, genetic susceptibility to inflammation correlated with an increased risk of epilepsy. Mounting evidence thus supports the hypothesis that inflammation may contribute to epileptogenesis and cause neuronal injury in epilepsy. We provide an overview of the current knowledge that implicates brain inflammation as a common predisposing factor in epilepsy, particularly childhood epilepsy.
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影响因子：
5.3
作者：
Borges, K;Gearing, M;Dingledine, R
通讯作者：
Dingledine, R
影响因子：
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作者：
Campbell, IL
通讯作者：
Campbell, IL
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5
作者：
Aronica, E;Gorter, JA;Troost, D
通讯作者：
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作者：
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通讯作者：
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影响因子：
1.9
作者：
ASO, K;SCHER, MS;BARMADA, MA
通讯作者：
BARMADA, MA