Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
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脂质代谢调节剂人羟基类固醇脱氢酶样2（HSDL2）调节宫颈癌细胞增殖和转移
DOI：
10.1111/jcmm.16461
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发表时间：
2021-05
影响因子：
5.3
通讯作者：
Lin Z
中科院分区：
文献类型：
--
作者：
Yang Y;Han A;Wang X;Yin X;Cui M;Lin Z
人羟基类固醇脱氢酶样2 （HSDL2）是一种有效的癌症调节剂，也参与脂质代谢，但HSDL2在宫颈癌中的作用以及它是否通过脂质代谢调节宫颈癌的进展尚不清楚。在本研究中，我们发现HSDL2的过表达与宫颈癌的进展有关，包括淋巴结转移和复发。HSDL2可作为宫颈癌早期诊断的新标志物。HSDL2还通过EMT启动和促进宫颈癌细胞（Hela、C33A和SiHa）的增殖、侵袭和迁移，从而促进肿瘤发生。有趣的是，我们还研究了HSDL2通过调节脂质代谢参与肿瘤发生。总之，我们的研究结果对HSDL2的功能有了新的认识，可能成为预后的生物标志物和新的治疗靶点。
Human hydroxysteroid dehydrogenase‐like 2 (HSDL2) is a potent regulator in cancers and is also involved in lipid metabolism, but the role of HSDL2 in cervical cancer and whether it regulates the progress of cervical cancer through lipid metabolism remains unclear. In this study, we found that the overexpression of HSDL2 was in relation with cervical cancer progression including lymph nodes metastasis and recurrence. HSDL2 could serve as a novel marker of early diagnosis in cervical cancer. HSDL2 also gave impetus to tumorigenesis by initiating and promoting proliferation, invasion and migration of cervical cancer cells (Hela, C33A and SiHa) through EMT. Interestingly, we also searched that HSDL2 participated in oncogenesis by regulating lipid metabolism. In sum, our results gave the novel insight of HSDL2 functions which could be the potential for being the biomarker of prognosis and new target of therapy.
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影响因子：
5.7
作者：
Kim, Tae-Joong;Choi, Jung-Joo;Kim, Byoung-Gie
通讯作者：
Kim, Byoung-Gie
人羟基类固醇脱氢酶样蛋白 2 的 C 端甾醇载体蛋白 2 型 (SCP-2) 结构域的合成、纯化和晶体学研究
DOI：
10.1107/s2053230x15008559
发表时间：
2015-07-01
影响因子：
0.9
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影响因子：
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10.1080/07391102.2021.1896386
发表时间：
2021-03-01
影响因子：
4.4
作者：
Yu Yang;Zhao Guangrong;Wei Gu
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影响因子：
3.9
作者：
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通讯作者：
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