Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.
Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.
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激活的HER受体，以预测接受辅助内分泌治疗治疗的ER阳性乳腺癌患者的预后。
DOI：
10.1016/j.breast.2012.07.005
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发表时间：
2012-10
期刊：
影响因子：
3.9
通讯作者：
Rasmussen, Birgitte B.
中科院分区：
文献类型：
--
作者：
Larsen, Mathilde S.;Bjerre, Karsten;Lykkesfeldt, Anne E.;Giobbie-Hurder, Anita;Laenkholm, Anne-Vibeke;Henriksen, Katrine L.;Ejlertsen, Bent;Rasmussen, Birgitte B.
The four human epidermal growth factor receptors (HER1–4) are involved in growth stimulation and may play a role in endocrine resistance. The receptors form dimers, leading to activation by mutual phosphorylation. Our purpose was to explore the role of the activated receptors (pHER1, pHER2, pHER3) in endocrine treated breast cancer in terms of co-expression and association with disease-free survival (DFS) in 1062 patients with ER-positive tumors. Furthermore, HER2 amplification was evaluated. We found positive associations between the phosphorylated receptors. pHER1 and pHER3 were co-expressed with one or two of the other activated receptors in 85% and 89% of tumors, respectively, whereas pHER2 was co-expressed with the other activated receptors in 54% of tumors. Except for HER2, which was associated with poor prognosis, none of the remaining markers were associated with DFS. However, frequent co-expression indicates a role of the other HER-family members in activation of HER2.
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影响因子：
3.5
作者：
Lee, Youngseok;Cho, Sujin;Kim, Aeree
通讯作者：
Kim, Aeree
影响因子：
82.9
作者：
Kononen, J;Bubendorf, L;Kallioniemi, OP
通讯作者：
Kallioniemi, OP
DOI：
10.1186/bcr2719
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Pinhel IF;Macneill FA;Hills MJ;Salter J;Detre S;A'hern R;Nerurkar A;Osin P;Smith IE;Dowsett M
通讯作者：
Dowsett M
HER4/4ICD雌激素受体共激活剂和仅BH3蛋白是他莫昔芬诱导的凋亡的效应因子。
影响因子：
11.2
作者：
Naresh, Anjali;Thor, Ann D.;Edgerton, Susan M.;Torkko, Kathleen C.;Kumar, Rakesh;Jones, Frank E.
通讯作者：
Jones, Frank E.
影响因子：
7.3
作者：
Amin DN;Campbell MR;Moasser MM
通讯作者：
Moasser MM