Orthologous gene-expression profiling in multi-species models: search for candidate genes.

Orthologous gene-expression profiling in multi-species models: search for candidate genes.
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DOI:
10.1186/gb-2004-5-5-r34
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发表时间:
2004
期刊:
影响因子:
12.3
通讯作者:
Garcia JG
Garcia JG
中科院分区:
生物学1区
文献类型:
--
作者:
Grigoryev DN;Ma SF;Irizarry RA;Ye SQ;Quackenbush J;Garcia JG

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An analytical approach that simultaneously evaluates multi-species experimental models is presented. This approach may be a useful tool in the selection of process-related candidate genes. Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.
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