Roles of NMDA and dopamine in food-foraging decision-making strategies of rats in the social setting.
Roles of NMDA and dopamine in food-foraging decision-making strategies of rats in the social setting.
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NMDA 和多巴胺在社交环境下大鼠食物觅食决策策略中的作用
DOI：
10.1186/s12868-015-0233-8
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发表时间：
2016-01-11
期刊：
影响因子：
2.4
通讯作者：
Li CQ
中科院分区：
文献类型：
--
作者：
Li F;Cao WY;Huang FL;Kang WJ;Zhong XL;Hu ZL;Wang HT;Zhang J;Zhang JY;Dai RP;Zhou XF;Li CQ
在高度复杂的社会环境中，动物追求目标的动机不仅取决于该目标的内在属性，还取决于决策动物是否认为该目标是最可取的。模仿欲望指的是一个主体对另一个主体已经拥有的物体的偏好。到目前为止，还没有合适的动物模型来研究模仿欲望是否在指导决策过程中起作用。此外，决策过程的神经药理学基础还没有被很好地理解。在这项研究中，我们使用动物模型(大鼠)来研究一种新的食物觅食决策范式，无论有没有模仿欲望的范式。面对在竞争环境中觅食的选择，大鼠更倾向于寻找理想的对象，这表明了老鼠的决策能力。值得注意的是，用非竞争性N-甲基-d-天冬氨酸受体拮抗剂MK-801处理，而不用多巴胺D1或D2受体拮抗剂SCH23390和氟哌啶醇处理，当笼子里有竞争的常驻鼠时，抑制了觅食偏好。这三种拮抗剂都没有影响它们对美味食物的觅食偏好。此外，MK-801和SCH23390能够消除在复杂的社会环境中对标准觅食活动的理想环境影响，但不能消除氟哌啶醇。这些结果强调了模拟欲望对大鼠觅食决策产生强大影响的概念，并进一步说明了谷氨酸和多巴胺能系统在调节这些过程中的各种作用。
In highly complex social settings, an animal’s motivational drive to pursue an object depends not only on the intrinsic properties of the object, but also on whether the decision-making animal perceives an object as being the most desirable among others. Mimetic desire refers to a subject’s preference for objects already possessed by another subject. To date, there are no appropriate animal models for studying whether mimetic desire is at play in guiding the decision-making process. Furthermore, the neuropharmacological bases of decision-making processes are not well understood. In this study, we used an animal model (rat) to investigate a novel food-foraging paradigm for decision-making, with or without a mimetic desire paradigm. Faced with the choice of foraging in a competitive environment, rats preferred foraging for the desirable object, indicating the rats’ ability for decision-making. Notably, treatment with the non-competitive N-methyl-d-aspartate receptor antagonist MK-801, but not with the dopamine D1 or D2 receptor antagonists, SCH23390 and haloperidol, respectively, suppressed the food foraging preference when there was a competing resident rat in the cage. None of these three antagonists affected the food-foraging preference for palatable food. Moreover, MK-801 and SCH23390, but not haloperidol, were able to abolish the desirable environment effect on standard food-foraging activities in complex social settings. These results highlight the concept that mimetic desire exerts a powerful influence on food-foraging decision-making in rats and, further, illustrate the various roles of the glutamatergic and dopaminergic systems in mediating these processes.
影响因子：
3.4
作者：
Jones-Cage, Chris;Stratford, Thomas R.;Wirtshafter, David
通讯作者：
Wirtshafter, David