Differential effects of the adenosine A₂A agonist CGS-21680 and haloperidol on food-reinforced fixed ratio responding in the rat.
Differential effects of the adenosine A₂A agonist CGS-21680 and haloperidol on food-reinforced fixed ratio responding in the rat.
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DOI：
10.1007/s00213-011-2467-1
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发表时间：
2012-03
影响因子：
3.4
通讯作者：
Wirtshafter, David
中科院分区：
文献类型：
--
作者：
Jones-Cage, Chris;Stratford, Thomas R.;Wirtshafter, David
关键词：
以往的研究表明，腺苷A2A受体与多巴胺D2受体共同定位于纹状体神经元。这两个受体的激活在许多情况下具有拮抗作用，这表明刺激腺苷A2a受体可能具有类似于阻断多巴胺D2受体所产生的行为影响，但这种可能性已在有限的情况下进行了调查。我们比较了腺苷A2A激动剂CGS-21680和首选的D2多巴胺拮抗剂氟哌啶醇在多巴胺阻断产生独特的行为效应模式的情况下的效果。将6只大鼠按固定比例15次强化训练，分别注射不同剂量的CGS-21680(0.064、0.128、0.25 mg/kg)和氟哌啶醇(0.25、0.1 mg/kg)。氟哌啶醇对杠杆按压有剂量依赖性的抑制作用，在整个测试过程中，平均应答率下降。CGS-21680也产生了剂量依赖的反应抑制，但这种影响没有在时间上分级，在整个治疗过程中，反应同样受到抑制。此外，CGS-21680增加强化后停顿时间的程度比氟哌啶醇大得多。在这项任务中，cgs-21680的行为效应与氟哌啶醇所产生的效应不同。对这种差异有几种可能的解释，最有可能的是，观察到的CGS-21680的行为效应是由D2受体表达的纹状体神经元以外的部位的作用造成的。
Previous studies have shown that adenosine A2A receptors are colocalized with dopamine D2 receptors on striatal neurons. Activation of these two receptors has antagonistic effects under a number of conditions suggesting that stimulation of adenosine A2A receptors may have behavioral effects resembling those produced by blockade of dopamine D2 receptors, but this possibility has been investigated in a limited number of situations. We compared the effects of the adenosine A2A agonist CGS-21680 and the preferential D2 dopamine antagonist haloperidol in a situation in which dopamine blockade produces a distinctive pattern of behavioral effects. Six rats were trained to lever press for food reward on a fixed ratio 15 schedule of reinforcement and then tested after being injected with various doses of CGS-21680 (0.064, 0.128, and 0.25 mg/kg) and haloperidol (0.25 and 0.1 mg/kg). Haloperidol produced a dose-dependent suppression of lever pressing with mean response rates declining across the duration of the test session. CGS-21680 also produced a dose-dependent suppression of responding, but this effect was not temporally graded, and responding was equivalently suppressed across the duration of the session. Additionally, CGS-21680 increased post-reinforcement pause duration to a much greater extent than did haloperidol. On this task, the behavioral effects of CGS-21680 do not resemble those produced by haloperidol. Several explanations of this discrepancy are possible, the most likely being that the observed behavioral effects of CGS-21680 result from an action at a site other than D2 receptor-expressing striatal neurons.
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DOI：
10.1016/0169-328x(92)90173-9
发表时间：
1992-07-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
FINK, JS;WEAVER, DR;REPPERT, SM
通讯作者：
REPPERT, SM
DOI：
10.1111/j.1749-6632.1956.tb49639.x
发表时间：
1956-01-01
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
DEWS, PB
通讯作者：
DEWS, PB
影响因子：
3.3
作者：
MORELLI, M;PINNA, A;DICHIARA, G
通讯作者：
DICHIARA, G
影响因子：
3.1
作者：
Fuxe, K;Ferré, S;Franco, R
通讯作者：
Franco, R
影响因子：
3.4
作者：
Font, Laura;Mingote, Susana;Salamone, John D.
通讯作者：
Salamone, John D.