Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol.
Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol.
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DOI：
10.3389/fmed.2022.849214
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发表时间：
2022
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性疼痛已成为一个全球性的健康问题，导致多年的残疾和生活质量下降。由于对导致慢性疼痛发展的多种风险因素和分子机制的不完全理解，慢性疼痛的临床管理进展有限。急性至慢性疼痛特征（A2CPS）计划旨在表征生物标志物（脑成像，高通量分子筛选技术或“组学”，定量感觉测试，患者报告的结果评估和功能评估）的预测性质，以确定手术干预后将发展为慢性疼痛的个体。A2CPS是一项多中心观察性研究，旨在研究生物标志物和集体生物特征（几种个体生物标志物的组合），这些生物标志物和集体生物特征可预测膝关节置换术和胸外科手术后慢性疼痛的易感性或恢复力。本手稿概述了数据收集方法和程序，旨在标准化多个临床研究中心和机构的数据收集。在手术前和手术后3个月内评估疼痛相关生物标志物，用作手术后6个月患者报告结果的预测因子。这项前瞻性观察性研究的数据集将提供给A2CPS联盟内部和外部的研究人员，以促进对从急性到慢性术后疼痛转变的理解。
Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.
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影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
DOI：
10.1097/ajp.0b013e3181f195ba
发表时间：
2010-11
期刊：
The Clinical journal of pain
影响因子：
--
作者：
Butler SF;Budman SH;Fanciullo GJ;Jamison RN
通讯作者：
Jamison RN
影响因子：
9
作者：
Borsook D;Kussman BD;George E;Becerra LR;Burke DW
通讯作者：
Burke DW
影响因子：
7.4
作者：
Bonini P;Kind T;Tsugawa H;Barupal DK;Fiehn O
通讯作者：
Fiehn O
影响因子：
7.4
作者：
Butler, Stephen F.;Budman, Simon H.;Jamison, Robert N.
通讯作者：
Jamison, Robert N.