Treatment of Atopic Cough Caused by Basidiomycetes Antigen with Low-dose Itraconazol
Treatment of Atopic Cough Caused by Basidiomycetes Antigen with Low-dose Itraconazol
复制标题
小剂量伊曲康唑治疗担子菌抗原引起的特应性咳嗽
作者：
H. Ogawa;M. Fujimura;Y. Tofuku
我们报告两例过敏性咳嗽由于担子菌抗原。一名患者是一名27岁的女性，另一名是一名17岁的男孩。这两个病人都是因为严重的干咳来我院就诊的。他们没有支气管对乙酰甲胆碱的高反应性或支气管张力升高。支气管扩张剂治疗对他们的咳嗽无效。她的症状在她的办公室恶化，而他的症状在他的家里恶化，这表明在他们的环境中存在病原体。从该妇女的办公室和该男孩的家里分离出了担子菌，用担子菌抗原进行的支气管激发试验呈阳性。低剂量伊曲康唑（50或100毫克/天）给予两个星期消除咳嗽的患者。这是第一个报告描述的有效性低剂量抗真菌治疗特应性咳嗽引起的担子菌抗原
We report two patients with atopic cough due toBasidiomycetesantigen. One patient was a 27 year-old woman and the other was a 17 year-old boy. Both patients visited our hospital because of severe nonproductive cough. They did not have bronchial hyperresponsiveness to methacholine or heightened bronchomotor tone. Bronchodilator therapy was not effective for their cough. Her symptoms worsened in her office and his in his house, suggesting existence of etiologic agent(s) in their environments.Basidiomyceteswas isolated from the woman’s office and from the boy’s house, and the bronchoprovocation test withBasidiomycetesantigen was positive. Low dose itraconazol (50 or 100 mg/day) given for two weeks eliminated cough in both patients. This is the first report describing the effectiveness of low dose antifungal therapy for atopic cough caused byBasidiomycetesantigen
影响因子：
10
作者：
Fujimura, M;Ogawa, H;Nishi, K
通讯作者：
Nishi, K