Thermal nociceptive properties of trigeminal afferent neurons in rats.
Thermal nociceptive properties of trigeminal afferent neurons in rats.
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DOI：
10.1186/1744-8069-6-39
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发表时间：
2010-07-07
期刊：
影响因子：
3.3
通讯作者：
Yeomans DC
中科院分区：
文献类型：
--
作者：
Cuellar JM;Manering NA;Klukinov M;Nemenov MI;Yeomans DC
虽然对支配机体的伤害性传入神经的研究已经进行了很多年，但对三叉神经传入神经的生物学研究却很少。特别是，很少有人知道三叉神经伤害感受器对热的反应，几乎没有在大鼠。本研究使用高度可控和可重复的二极管激光刺激器来研究三叉神经传入对有害皮肤加热的激活。本实验结果表明，三叉神经的温度感受器不同于支配肢体的单伤害感受器。与躯体传入神经元相比，三叉神经伤害感受器具有相当慢的动作电位传导速度和较低的温度阈值。另一方面，支配两个组织区域的伤害感受器分为对短脉冲、高速率皮肤加热作出响应的伤害感受器和对长脉冲、低速率皮肤加热作出响应的伤害感受器。本文提供了在文献中的第一个描述在大鼠体内的热感受器的特性。这两个独立的群体的发现与支配爪子的C和A-δ热感受器之间的分离一致，但在温度阈值和平均传导速度方面存在显着差异。对支配爪子皮肤的传入神经元的温度响应特性的理解在许多机械发现中是至关重要的，一些导致新的疼痛疗法。对三叉神经伤害感受器的清楚了解可能同样有助于三叉神经疼痛机制和潜在治疗的研究。
Although nociceptive afferents innervating the body have been heavily studied form many years, much less attention has been paid to trigeminal afferent biology. In particular, very little is known concerning trigeminal nociceptor responses to heat, and almost nothing in the rat. This study uses a highly controlled and reproducible diode laser stimulator to investigate the activation of trigeminal afferents to noxious skin heating. The results of this experiment demonstrate that trigeminal thermonociceptors are distinct from themonociceptors innervating the limbs. Trigeminal nociceptors have considerably slower action potential conduction velocities and lower temperature thresholds than somatic afferent neurons. On the other hand, nociceptors innervating both tissue areas separate into those that respond to short pulse, high rate skin heating and those that respond to long pulse, low rate skin heating. This paper provides the first description in the literature of the in vivo properties of thermonociceptors in rats. These finding of two separate populations aligns with the separation between C and A-delta thermonociceptors innervating the paw, but have significant differences in terms of temperature threshold and average conduction velocities. An understanding of the temperature response properties of afferent neurons innervating the paw skin have been critical in many mechanistic discoveries, some leading to new pain therapies. A clear understanding of trigeminal nociceptors may be similarly useful in the investigation of trigeminal pain mechanisms and potential therapies.
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