Kidney Function Is Not Related to Brain Amyloid Burden on PET Imaging in The 90+ Study Cohort.
Kidney Function Is Not Related to Brain Amyloid Burden on PET Imaging in The 90+ Study Cohort.
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DOI：
10.3389/fmed.2021.671945
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发表时间：
2021
影响因子：
3.9
通讯作者：
Paganini-Hill A
中科院分区：
文献类型：
--
作者：
Lau WL;Fisher M;Fletcher E;DeCarli C;Troutt H;Corrada MM;Kawas C;Paganini-Hill A
认知能力下降在慢性肾脏病 (CKD) 中很常见。虽然该人群存在血管性认知障碍的证据很充分，但阿尔茨海默病病理学的作用尚不清楚。我们评估了 90+ 研究中 166 名参与者的血清胱抑素 C 估计肾小球滤过率 (eGFR)、脑淀粉样蛋白-β 正电子发射断层扫描 (PET) 成像和认知功能。平均年龄为 93 岁（范围 90-107），其中 101 名（61%）为女性； 107 名参与者的认知状态正常，而 59 名参与者有认知障碍，无痴呆 (CIND) 或痴呆。半胱氨酸蛋白酶抑制剂 C 的平均值±标准差为 1.59 ± 0.54 mg/L，eGFR 为 40.7 ± 18.7 ml/min/1.73m2。较高的β淀粉样蛋白负荷与痴呆相关，但与年龄、糖尿病、高血压或心血管疾病无关。我们发现脑淀粉样蛋白-β 负荷与胱抑素 C eGFR 之间没有关联。我们之前报道过，在同一组最年长的成年人（90 岁以上）中，肾功能与认知和脑微出血有关。总的来说，这些发现表明，微血管而不是阿尔茨海默氏病的病理学导致了该人群中与 CKD 相关的认知功能障碍。
Cognitive decline is common in chronic kidney disease (CKD). While the evidence of vascular cognitive impairment in this population is robust, the role of Alzheimer's pathology is unknown. We evaluated serum cystatin C-estimated glomerular filtration rate (eGFR), brain amyloid-β positron emission tomography (PET) imaging, and cognitive function in 166 participants from The 90+ Study. Mean age was 93 years (range 90-107) and 101 (61%) were women; 107 participants had normal cognitive status while 59 participants had cognitive impairment no dementia (CIND) or dementia. Mean ± standard deviation cystatin C was 1.59 ± 0.54 mg/L with eGFR 40.7 ± 18.7 ml/min/1.73m2. Higher amyloid-β burden was associated with dementia, but not with age, diabetes, hypertension, or cardiovascular disease. We found no association between brain amyloid-β burden and cystatin C eGFR. We previously reported that kidney function was associated with cognition and cerebral microbleeds in the same cohort of oldest-old adults (90+ years old). Collectively, these findings suggest that microvascular rather than Alzheimer's pathology drives CKD-associated cognitive dysfunction in this population.
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DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
2.6
作者：
Oh MY;Lee H;Kim JS;Ryu WS;Lee SH;Ko SB;Kim C;Kim CH;Yoon BW
通讯作者：
Yoon BW
影响因子：
16.2
作者：
Murray AM;Barzilay JI;Lovato JF;Williamson JD;Miller ME;Marcovina S;Launer LJ;Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) Substudy Investigators
通讯作者：
Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) Substudy Investigators
影响因子：
4.2
作者：
Klunk WE
通讯作者：
Klunk WE
影响因子：
6
作者：
Deng, A;Irizarry, MC;Rebeck, GW
通讯作者：
Rebeck, GW