Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia.
Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia.
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DOI：
10.1016/j.neurobiolaging.2011.09.006
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发表时间：
2011-12
影响因子：
4.2
通讯作者：
Klunk WE
中科院分区：
文献类型：
--
作者：
Klunk WE
自从近十年前引入淀粉样蛋白成像以来，这项技术已经获得了广泛的使用和接受。最近，已经开始出现淀粉样蛋白成像用于检测抗淀粉样蛋白治疗效果的公开报道。本综述将考虑淀粉样蛋白成像在阿尔茨海默病治疗药物开发和评价中的应用。目前的证据有关死后相关的体内淀粉样蛋白成像数据被认为是。淀粉样蛋白成像的应用筛选受试者的试验和使用作为一个结果的措施进行了讨论，在体内淀粉样蛋白信号的纵向变化。虽然这篇综述的大部分是针对有症状的痴呆患者，但也考虑了淀粉样蛋白成像在非痴呆受试者中的应用。描述了通过淀粉样蛋白成像和CSF测量进行脑淀粉样蛋白评估的相似性和差异，并提出了进一步研究以提高淀粉样蛋白PET对临床试验的适用性的议程。
Since the introduction of amyloid imaging nearly ten years ago, this technique has gained widespread use and acceptance. More recently, published reports have begun to appear in which amyloid imaging is used to detect the effects of anti-amyloid therapies. This review will consider the issues involved in the use of amyloid imaging in the development and evaluation of drugs for the treatment of Alzheimer disease. Current evidence regarding the postmortem correlates of in vivo amyloid imaging data is considered. The application of amyloid imaging to screening subjects for trials and use as an outcome measure is discussed in light of longitudinal changes in the in vivo amyloid signal. While the bulk of this review is directed at symptomatic patients with dementia, consideration is given to the use of amyloid imaging in non-demented subjects as well. Similarities and differences of cerebral amyloid assessment by amyloid imaging and CSF measurements are delineated and an agenda for further research to improve the applicability of amyloid PET to clinical trials is proposed.
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影响因子：
2.6
作者：
Devanand DP;Mikhno A;Pelton GH;Cuasay K;Pradhaban G;Dileep Kumar JS;Upton N;Lai R;Gunn RN;Libri V;Liu X;van Heertum R;Mann JJ;Parsey RV
通讯作者：
Parsey RV
影响因子：
2.1
作者：
Butters, Meryl A.;Klunk, William E.;Meltzer, Carolyn C.
通讯作者：
Meltzer, Carolyn C.
影响因子：
4.2
作者：
Ball, M;Braak, H;Khachaturian, Z
通讯作者：
Khachaturian, Z
基础大脑代谢可能会调节Abeta在轻度认知障碍中的认知作用：大脑储备的一个例子。
DOI：
10.1523/jneurosci.3669-09.2009
发表时间：
2009-11-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cohen AD;Price JC;Weissfeld LA;James J;Rosario BL;Bi W;Nebes RD;Saxton JA;Snitz BE;Aizenstein HA;Wolk DA;Dekosky ST;Mathis CA;Klunk WE
通讯作者：
Klunk WE
影响因子：
4.2
作者：
Furst AJ;Rabinovici GD;Rostomian AH;Steed T;Alkalay A;Racine C;Miller BL;Jagust WJ
通讯作者：
Jagust WJ