Smooth-pursuit eye-movement-related neuronal activity in macaque nucleus reticularis tegmenti pontis.
Smooth-pursuit eye-movement-related neuronal activity in macaque nucleus reticularis tegmenti pontis.
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猕猴脑桥网状核中平滑追踪眼球运动相关的神经元活动。
DOI：
10.1152/jn.00117.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Yee,RobertD
中科院分区：
文献类型：
--
作者：
Suzuki,DavidA;Yamada,Tetsuto;Yee,RobertD
神经元的反应，在顺利追求眼球运动过程中观察到的记录从脑桥网状被盖核（rNRTP）的吻侧部分的细胞。这些反应被归类为平滑追踪眼速（78%）或眼加速度（22%）。单独的rNRTP细胞群体编码静态眼位置。对追踪眼速度的灵敏度平均为0.81尖峰/秒/°/秒，而对追踪眼加速度的平均灵敏度为0.20尖峰/秒/°/秒2。的眼速度细胞与水平偏好的追求反应，56%的最佳反应，逆向顺利追求眼球运动和44%的首选ipsiversive追求。对于垂直追求偏好的细胞，61%的人喜欢向上追求，39%的人喜欢向下追求。方向选择性很宽，在距离最佳方向±85°的平滑追踪方向上观察到50%的最大响应幅度。一些rNRTP细胞的活动与眼睛位置呈线性相关，平均灵敏度为2.1峰/秒每度。在某些细胞中，即使这些细胞不编码眼睛位置，但在平滑追踪眼球运动期间的反应幅度也会受到眼睛位置的影响。平均而言，以屏幕中心的一侧为中心的追踪引起的响应是以屏幕中心为中心的追踪获得的响应幅度的73%。对于以对面为中心的追踪，平均响应是在屏幕中心获得的响应的127%。结果提供了一个神经元的理由缓慢，追求样的眼球运动诱发rNRTP微刺激和赤字的顺利追求眼球运动观察到鹅膏蕈氨酸注射到rNRTP。更全面地说，研究结果支持了额叶和补充眼场-rNRTP-小脑通路参与控制平稳追踪眼球运动的概念。
Neuronal responses that were observed during smooth-pursuit eye movements were recorded from cells in rostral portions of the nucleus reticularis tegmenti pontis (rNRTP). The responses were categorized as smooth-pursuit eye velocity (78%) or eye acceleration (22%). A separate population of rNRTP cells encoded static eye position. The sensitivity to pursuit eye velocity averaged 0.81 spikes/s per °/s, whereas the average sensitivity to pursuit eye acceleration was 0.20 spikes/s per °/s2. Of the eye-velocity cells with horizontal preferences for pursuit responses, 56% were optimally responsive to contraversive smooth-pursuit eye movements and 44% preferred ipsiversive pursuit. For cells with vertical pursuit preferences, 61% preferred upward pursuit and 39% preferred downward pursuit. The direction selectivity was broad with 50% of the maximal response amplitude observed for directions of smooth pursuit up to ±85° away from the optimal direction. The activities of some rNRTP cells were linearly related to eye position with an average sensitivity of 2.1 spikes/s per deg. In some cells, the magnitude of the response during smooth-pursuit eye movements was affected by the position of the eyes even though these cells did not encode eye position. On average, pursuit centered to one side of screen center elicited a response that was 73% of the response amplitude obtained with tracking centered at screen center. For pursuit centered on the opposite side, the average response was 127% of the response obtained at screen center. The results provide a neuronal rationale for the slow, pursuit-like eye movements evoked with rNRTP microstimulation and for the deficits in smooth-pursuit eye movements observed with ibotenic acid injection into rNRTP. More globally, the results support the notion of a frontal and supplementary eye field-rNRTP-cerebellum pathway involved with controlling smooth-pursuit eye movements.
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作者：
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DOI：
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DOI：
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影响因子：
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