Generation of toxic degradation products by sonication of Pluronic® dispersants: implications for nanotoxicity testing.
Generation of toxic degradation products by sonication of Pluronic® dispersants: implications for nanotoxicity testing.
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DOI：
10.3109/17435390.2012.736547
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发表时间：
2013-11
期刊：
影响因子：
5
通讯作者：
Draper RK
中科院分区：
文献类型：
--
作者：
Wang R;Hughes T;Beck S;Vakil S;Li S;Pantano P;Draper RK
泊洛沙姆（以商品名Pluronic®已知）是三嵌段共聚物表面活性剂，其含有各种尺寸的两个聚乙二醇嵌段和一个聚丙二醇嵌段。泊洛沙姆广泛用作纳米毒性研究的纳米颗粒分散剂，其中纳米颗粒与分散剂超声处理以制备悬浮液。已知泊洛沙姆可以在超声处理期间降解，并且活性氧物质有助于降解过程。然而，泊洛沙姆降解产物对哺乳动物细胞有毒的可能性尚未得到充分研究。我们在此报告，在存在或不存在多壁碳纳米管（MWNT）的情况下超声处理的泊洛沙姆188（Pluronic ® F-68）和泊洛沙姆407（Pluronic® F-127）的水溶液可以对培养的细胞具有高度毒性。此外，毒性与超声波降解的聚合物。这些研究结果表明，在解释纳米毒性研究结果时应谨慎使用，其中分散剂的潜在超声降解不受控制。
Poloxamers (known by the trade name Pluronic®) are triblock copolymer surfactants that contain two polyethylene glycol blocks and one polypropylene glycol block of various sizes. Poloxamers are widely used as nanoparticle dispersants for nanotoxicity studies wherein nanoparticles are sonicated with a dispersant to prepare suspensions. It is known that poloxamers can be degraded during sonication and that reactive oxygen species contribute to the degradation process. However, the possibility that poloxamer degradation products are toxic to mammalian cells has not been well studied. We report here that aqueous solutions of poloxamer 188 (Pluronic® F-68) and poloxamer 407 (Pluronic® F-127) sonicated in the presence or absence of multi-walled carbon nanotubes (MWNTs) can became highly toxic to cultured cells. Moreover, toxicity correlated with the sonolytic degradation of the polymers. These findings suggest that caution should be used in interpreting the results of nanotoxicity studies where the potential sonolytic degradation of dispersants was not controlled.
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影响因子：
2.9
作者：
KURFURST, MM
通讯作者：
KURFURST, MM
影响因子：
4.9
作者：
Wang R;Mikoryak C;Li S;Bushdiecker D 2nd;Musselman IH;Pantano P;Draper RK
通讯作者：
Draper RK
影响因子：
3.3
作者：
Sostaric, JZ;Riesz, P
通讯作者：
Riesz, P
影响因子：
3.9
作者：
BAHADUR, P;LI, PY;BROWN, W
通讯作者：
BROWN, W
影响因子：
4.2
作者：
NEPPIRAS, EA
通讯作者：
NEPPIRAS, EA