Evaluation of development-specific targets for antiepileptogenic therapy using rapid kindling.
Evaluation of development-specific targets for antiepileptogenic therapy using rapid kindling.
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DOI：
10.1111/j.1528-1167.2010.02607.x
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发表时间：
2010-07
期刊：
影响因子：
5.6
通讯作者：
Mazarati A
中科院分区：
文献类型：
--
作者：
Sankar R;Auvin S;Kwon YS;Pineda E;Shin D;Mazarati A
我们使用快速海马点燃的方法来评估一些抗惊厥药物的潜在抗癫痫疗效。该方法提供了比基于癫痫发生的传统点燃或癫痫持续状态后模型的方法更高的通量。这种“压缩癫痫发生”模型也允许年龄依赖性药理学靶点的研究，并根据其年龄特异性抗癫痫疗效区分AED。我们发现瑞替加滨是最有效的抗惊厥治疗在早期发展。托吡酯似乎最有效的进一步沿着发展，而有些药物没有表现出年龄特异性的影响。该方法也重现了以前拉莫三嗪的一些矛盾的药理学结果。虽然该模型用于筛选抗癫痫治疗的实用性需要进一步验证，但它引入了进行开发特异性测试的能力和比传统方法更快的通量。
We used the method of rapid hippocampal kindling to assess the potential antiepileptogenic efficacy of a number of anticonvulsant medications. This method afforded a higher throughput than methods based on traditional kindling or post-status epilepticus models of epileptogenesis. This “compressed epileptogenesis” model also permitted the study of age-dependent pharmacologic targets, and distinguished among AEDs based on their age-specific antiepileptogenic efficacy. We found retigabine to be the most effective anticonvulsant therapy during early development. Topiramate seemed most effective further along development, while some drugs did not demonstrate an age-specific effect. The method also reproduced some of the paradoxical pharmacologic findings previously shown with lamotrigine. While the utility of this model for screening the antiepileptogenic therapies requires further validation it introduces the ability to undertake development-specific testing and a more rapid throughput than conventional methods.
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影响因子：
2.2
作者：
Nissinen, J;Large, CH;Pitkänen, A
通讯作者：
Pitkänen, A
影响因子：
5.6
作者：
Mazarati, Andrey;Wu, Jim;Sankar, Raman
通讯作者：
Sankar, Raman
DOI：
10.1016/0165-3806(91)90116-z
发表时间：
1991-07-16
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
MICHELSON, HB;LOTHMAN, EW
通讯作者：
LOTHMAN, EW
DOI：
10.1124/jpet.106.104703
发表时间：
2006-08-01
影响因子：
3.5
作者：
Mazarati, Andrey;Lundstrom, Linda;Sankar, Raman
通讯作者：
Sankar, Raman
影响因子：
5.6
作者：
White, HS
通讯作者：
White, HS