Data-driven optimization and evaluation of 2D EPI and 3D PRESTO for BOLD fMRI at 7 Tesla: I. Focal coverage.
Data-driven optimization and evaluation of 2D EPI and 3D PRESTO for BOLD fMRI at 7 Tesla: I. Focal coverage.
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DOI：
10.1016/j.neuroimage.2010.12.086
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发表时间：
2011-04-01
期刊：
影响因子：
5.7
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Barry, Robert L.;Strother, Stephen C.;Gatenby, J. Christopher;Gore, John C.
关键词：
血氧水平依赖 (BOLD) 功能磁共振成像 (fMRI) 通常使用 2D 单次回波平面成像 (EPI) 进行。然而，7 Tesla (T) 下的单次 EPI 通常会遭受严重的几何失真（由于相位编码 (PE) 方向上的低带宽 (BW)）和放大的生理噪声。最近的研究表明，PRESTO 等 3D 多镜头序列可以提供可比的 BOLD 对比度噪声比，同时增加体积覆盖范围并减少几何失真。因此，在两个面内分辨率下的 2D 和 3D 采集序列之间进行了四向组级比较。 fMRI 数据的质量通过使用 NAIRS（非参数预测、激活、影响和再现性重采样）的预测和再现性指标进行评估。通过选择共同最大化预测和再现性的主成分数量，针对每个采集策略优化了组激活图，并且在阳性 BOLD 变化的敏感性和特异性方面表现出良好的一致性。高分辨率 EPI 显示了四个采集序列中最高的 z 分数；然而，它在PE方向上具有最低的BW（导致最严重的几何扭曲）和有限的空间覆盖，并且还通过周围神经刺激（PNS）引起一些受试者的不适。相比之下，PRESTO 还具有较高的 z 分数（在匹配的面内分辨率方面高于 EPI）、PE 方向上最高的 BW（生成具有卓越几何保真度的图像）、全脑覆盖的潜力，并且没有报道 PNS。这项研究提供了证据支持使用 3D 多次采集序列代替单次 EPI 进行 7T 超高场 BOLD fMRI。
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is commonly performed using 2D single-shot echo-planar imaging (EPI). However, single-shot EPI at 7 Tesla (T) often suffers from significant geometric distortions (due to low bandwidth (BW) in the phase-encode (PE) direction) and amplified physiological noise. Recent studies have suggested that 3D multi-shot sequences such as PRESTO may offer comparable BOLD contrast-to-noise ratio with increased volume coverage and decreased geometric distortions. Thus, a four-way group-level comparison was performed between 2D and 3D acquisition sequences at two in-plane resolutions. The quality of fMRI data was evaluated via metrics of prediction and reproducibility using NPAIRS (Non-parametric Prediction, Activation, Influence and Reproducibility re-Sampling). Group activation maps were optimized for each acquisition strategy by selecting the number of principal components that jointly maximized prediction and reproducibility, and showed good agreement in sensitivity and specificity for positive BOLD changes. High-resolution EPI exhibited the highest z-scores of the four acquisition sequences; however, it suffered from the lowest BW in the PE direction (resulting in the worst geometric distortions) and limited spatial coverage, and also caused some subject discomfort through peripheral nerve stimulation (PNS). In comparison, PRESTO also had high z-scores (higher than EPI for a matched in-plane resolution), the highest BW in the PE direction (producing images with superior geometric fidelity), the potential for whole-brain coverage, and no reported PNS. This study provides evidence to support the use of 3D multi-shot acquisition sequences in lieu of single-shot EPI for ultra high field BOLD fMRI at 7T.
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