A placebo‐controlled clinical trial of remoxipride and chlorpromazine in newly admitted schizophrenic patients with acute exacerbation
A placebo‐controlled clinical trial of remoxipride and chlorpromazine in newly admitted schizophrenic patients with acute exacerbation
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瑞莫必利和氯丙嗪治疗新入院的急性加重精神分裂症患者的安慰剂对照临床试验
DOI：
10.1111/j.1600-0447.1990.tb05301.x
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发表时间：
1990
影响因子：
6.7
通讯作者：
Guy Chouinard
中科院分区：
文献类型：
--
作者：
Guy Chouinard
摘要我们进行了一项为期四周的双盲安慰剂对照研究，比较了瑞莫西必利（n=20）、氯丙嗪（n=21）和安慰剂（n=21）治疗新入院的精神分裂症急性加重患者的疗效。氯丙嗪在无效脱落率、临床总体印象量表（CGI）和简明精神病评定量表（BPRS）方面明显优于瑞莫昔必利。在与无效相关的脱落率、严重程度的护士总体印象（NGI）和阳性症状（幻觉行为和思维障碍因子）的BPRS测量方面，氯丙嗪往往优于安慰剂。我们无法检测到remoxipride和安慰剂之间的差异，除了remoxipride在以前对精神抑制剂反应良好的患者中更好。这两种药物诱导的帕金森症明显多于安慰剂，但不同的是：氯丙嗪诱导了两种类型的帕金森症运动功能减退和运动功能亢进症状，而瑞莫西必利诱导了运动功能亢进症状。氯丙嗪引起的心动过速、嗜睡、直立性头晕和口干比其他两种治疗方法更多，而瑞莫西必利的患者失眠比其他两种治疗方法更多。
Abstract We carried out a four‐week double‐blind placebo‐controlled study comparing remoxipride (n=20) to chlorpromazine (n=21) and placebo (n=21) in the treatment of newly admitted schizophrenic patients with acute exacerbation. Chlorpromazine was found to be significantly better than remoxipride on the dropout rate due to inefficacy, Clinical Global Impression (CGI) of severity of illness and Brief Psychiatric Rating Scale (BPRS). Chlorpromazine tended to be better than placebo on the dropout rate related to inefficacy, Nurse's Global Impression (NGI) of severity and on the BPRS measures of positive symptoms (hallucinatory behaviour and thinking disturbance factor). We were unable to detect a difference between remoxipride and placebo except that remoxipride was better in patients who had previously responded well to neuroleptics. Both drugs induced significantly more parkinsonism than placebo, but differently so: chlorpromazine induced both types of parkinsonism hypo‐ and hyper‐kinetic symptoms, whereas remoxipride induced hyperkinetic symptoms. Chlorpromazine caused more tachycardia, drowsiness, orthostatic dizziness, and dry mouth than the other two treatments, while patients on remoxipride suffered more from insomnia than those on the other two treatments.
D1 和 D2 激动剂对大鼠口腔运动的相反作用。
影响因子：
5
作者：
Johansson,P;Levin,E;Gunne,L;Ellison,G
通讯作者：
Ellison,G