Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all.
Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all.
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DOI：
10.1186/s13014-015-0462-0
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发表时间：
2015-08-07
期刊：
影响因子：
--
通讯作者：
Krawczyk PM
中科院分区：
文献类型：
--
作者：
Oei AL;Vriend LE;Crezee J;Franken NA;Krawczyk PM
目前可用的抗癌方式包括许多可以杀死恶性细胞的DNA损伤剂。然而，有效的DNA修复机制可以保护健康细胞和癌细胞免受治疗的影响，并有助于耐药性的发展。因此，基于造成DNA损伤的抗癌治疗可以受益于DNA修复的抑制。热疗-在升高的温度下治疗-在其他细胞过程中显著影响DNA修复，并且因此可以使（癌）细胞对DNA损伤剂敏感。这种效应已经被人们所知并在临床上应用了几十年，但热如何抑制DNA修复以及靶向哪些途径尚未完全阐明。在这篇综述中，我们试图总结高温对与癌症临床治疗相关的DNA修复途径的已知影响。此外，我们概述了热对DNA修复的影响和细胞对各种DNA损伤剂的敏感性之间的关系。
The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both healthy and cancer cells against the effects of treatment and contribute to the development of drug resistance. Therefore, anti-cancer treatments based on inflicting DNA damage can benefit from inhibition of DNA repair. Hyperthermia – treatment at elevated temperature – considerably affects DNA repair, among other cellular processes, and can thus sensitize (cancer) cells to DNA damaging agents. This effect has been known and clinically applied for many decades, but how heat inhibits DNA repair and which pathways are targeted has not been fully elucidated. In this review we attempt to summarize the known effects of hyperthermia on DNA repair pathways relevant in clinical treatment of cancer. Furthermore, we outline the relationships between the effects of heat on DNA repair and sensitization of cells to various DNA damaging agents.
影响因子：
8.8
作者：
Joiner, M C;Steel, G G;Stephens, T C
通讯作者：
Stephens, T C