Candidate biomarkers for genetic and clinicopathological diagnosis of endometrial cancer.
Candidate biomarkers for genetic and clinicopathological diagnosis of endometrial cancer.
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DOI：
10.3390/ijms140612123
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发表时间：
2013-06-06
影响因子：
5.6
通讯作者：
Aoki D
中科院分区：
文献类型：
--
作者：
Banno K;Nogami Y;Kisu I;Yanokura M;Umene K;Masuda K;Kobayashi Y;Yamagami W;Susumu N;Aoki D
最近在子宫内膜癌的频率增加，强调需要准确的诊断和改进治疗。目前的诊断仍基于常规病理指标，如临床分期、肿瘤分化、浸润深度、血管浸润等。然而，由于分子生物学的发展，子宫内膜癌的遗传机制已经逐渐确定，从而有可能找到新的诊断和治疗方法。新的子宫内膜癌候选生物标志物包括那些分子表观遗传突变，如microRNAs。这些生物标志物可能允许早期检测子宫内膜癌和预测结果，并可能有助于未来子宫内膜癌的个性化治疗。
The recent increase in the frequency of endometrial cancer has emphasized the need for accurate diagnosis and improved treatment. The current diagnosis is still based on conventional pathological indicators, such as clinical stage, tumor differentiation, invasion depth and vascular invasion. However, the genetic mechanisms underlying endometrial cancer have gradually been determined, due to developments in molecular biology, leading to the possibility of new methods of diagnosis and treatment planning. New candidate biomarkers for endometrial cancer include those for molecular epigenetic mutations, such as microRNAs. These biomarkers may permit earlier detection of endometrial cancer and prediction of outcomes and are likely to contribute to future personalized therapy for endometrial cancer.
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DOI：
10.1016/j.jsbmb.2007.09.020
发表时间：
2008-02-01
影响因子：
4.1
作者：
Doll, A.;Abal, M.;Reventos, J.
通讯作者：
Reventos, J.
影响因子：
2.3
作者：
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通讯作者：
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影响因子：
2.6
作者：
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通讯作者：
Aoki, Daisuke
影响因子：
4.7
作者：
Bogen，Kenneth T.
通讯作者：
Bogen，Kenneth T.
影响因子：
2.6
作者：
Bansal, Nisha;Yendluri, Vimala;Wenham, Robert M.
通讯作者：
Wenham, Robert M.