Gene body methylation in cancer: molecular mechanisms and clinical applications.
Gene body methylation in cancer: molecular mechanisms and clinical applications.
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DOI：
10.1186/s13148-022-01382-9
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发表时间：
2022-11-28
影响因子：
5.7
通讯作者：
Chen, Yongjun
中科院分区：
文献类型：
--
作者：
Wang, Qi;Xiong, Fei;Wu, Guanhua;Liu, Wenzheng;Chen, Junsheng;Wang, Bing;Chen, Yongjun
DNA甲基化是调控基因表达的重要表观遗传机制。迄今为止，大多数DNA甲基化研究都集中在基因启动子区域的CpG岛上，甲基化的机制和甲基化后基因表达的调控已经清楚地阐明。然而，全基因组甲基化研究表明，DNA甲基化不仅广泛存在于启动子中，而且存在于基因体中。基因体甲基化广泛参与许多基因的表达调控，与恶性肿瘤的发生、发展密切相关。本文就基因体甲基化模式的形成、转录调控及其与肿瘤的关系进行综述，为探讨基因体甲基化调控基因转录的机制及其在肿瘤学领域的意义和应用提供线索。
DNA methylation is an important epigenetic mechanism that regulates gene expression. To date, most DNA methylation studies have focussed on CpG islands in the gene promoter region, and the mechanism of methylation and the regulation of gene expression after methylation have been clearly elucidated. However, genome-wide methylation studies have shown that DNA methylation is widespread not only in promoters but also in gene bodies. Gene body methylation is widely involved in the expression regulation of many genes and is closely related to the occurrence and progression of malignant tumours. This review focusses on the formation of gene body methylation patterns, its regulation of transcription, and its relationship with tumours, providing clues to explore the mechanism of gene body methylation in regulating gene transcription and its significance and application in the field of oncology.
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影响因子：
46.9
作者：
Ball, Madeleine P.;Li, Jin Billy;Gao, Yuan;Lee, Je-Hyuk;LeProust, Emily M.;Park, In-Hyun;Xie, Bin;Daley, George Q.;Church, George M.
通讯作者：
Church, George M.
DOI：
10.1038/nrclinonc.2013.42
发表时间：
2013-05
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
通讯作者：
--
影响因子：
16
作者：
Charlet J;Duymich CE;Lay FD;Mundbjerg K;Dalsgaard Sørensen K;Liang G;Jones PA
通讯作者：
Jones PA
影响因子：
4.5
作者：
de Koning AP;Gu W;Castoe TA;Batzer MA;Pollock DD
通讯作者：
Pollock DD
影响因子：
4.8
作者：
Choi, Won-Young;Hwang, Ji-Hyun;Kim, Young-Joon
通讯作者：
Kim, Young-Joon