TRIM proteins in blood cancers.

TRIM proteins in blood cancers.
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DOI:
10.1007/s12079-017-0423-5
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发表时间:
2018-03
影响因子:
4.1
通讯作者:
Irvine AE
Irvine AE
中科院分区:
生物学2区
文献类型:
--
作者:
Crawford LJ;Johnston CK;Irvine AE

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泛素对蛋白质的翻译后修饰在调节许多细胞过程中起着重要作用。E3连接酶通过介导泛素向底物蛋白的转移来决定泛素化的特异性。TRIM蛋白家族是E3连接酶中最大的亚家族之一。越来越多的证据表明,TRIM蛋白的失调与多种疾病有关。在这篇综述中,我们重点关注TRIM蛋白在血液癌症中的参与。
Post-translational modification of proteins with ubiquitin plays a central role in regulating numerous cellular processes. E3 ligases determine the specificity of ubiquitination by mediating the transfer of ubiquitin to substrate proteins. The family of tripartite motif (TRIM) proteins make up one of the largest subfamilies of E3 ligases. Accumulating evidence suggests that dysregulation of TRIM proteins is associated with a variety of diseases. In this review we focus on the involvement of TRIM proteins in blood cancers.
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