Antimicrobial peptides for therapeutic applications: a review.
Antimicrobial peptides for therapeutic applications: a review.
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治疗应用的抗菌肽：综述。
DOI：
10.3390/molecules171012276
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发表时间：
2012-10-18
期刊：
影响因子：
--
通讯作者：
Lee BJ
中科院分区：
文献类型：
--
作者：
Seo MD;Won HS;Kim JH;Mishig-Ochir T;Lee BJ
抗菌肽（Antimicrobial peptides，AMP）具有广谱抗菌活性和与传统抗生素不同的作用机制，被认为是未来抗生素的潜在治疗来源。尽管抗菌肽作为新一代抗生素具有相当大的优势，但其临床和商业开发仍存在一些限制，如潜在的毒性、对蛋白酶的敏感性以及肽生产成本高。为了克服这些障碍，已经作出了广泛的努力。例如，引入不寻常的氨基酸或肽模拟物以避免蛋白水解降解，并且提出保留抗微生物活性的短肽的设计作为成本问题的解决方案。在这篇综述中，我们专注于小肽，特别是那些少于12个氨基酸，并提供了他们的三维结构和抗菌活性之间的关系的概述。还描述了开发具有较短序列的高活性AMP的努力。
Antimicrobial peptides (AMPs) have been considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and different mechanisms of action compared to conventional antibiotics. Although AMPs possess considerable benefits as new generation antibiotics, their clinical and commercial development still have some limitations, such as potential toxicity, susceptibility to proteases, and high cost of peptide production. In order to overcome those obstacles, extensive efforts have been carried out. For instance, unusual amino acids or peptido-mimetics are introduced to avoid the proteolytic degradation and the design of short peptides retaining antimicrobial activities is proposed as a solution for the cost issue. In this review, we focus on small peptides, especially those with less than twelve amino acids, and provide an overview of the relationships between their three-dimensional structures and antimicrobial activities. The efforts to develop highly active AMPs with shorter sequences are also described.
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影响因子：
2.9
作者：
Hwang, PM;Zhou, N;Vogel, HJ
通讯作者：
Vogel, HJ
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1046/j.1432-1033.2003.03587.x
发表时间：
2003-05-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
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通讯作者：
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影响因子：
56.9
作者：
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通讯作者：
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