The pathophysiological function of peroxisome proliferator-activated receptor-gamma in lung-related diseases.

The pathophysiological function of peroxisome proliferator-activated receptor-gamma in lung-related diseases.
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DOI:
10.1186/1465-9921-6-102
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发表时间:
2005-09-09
影响因子:
5.8
通讯作者:
Roufogalis BD
Roufogalis BD
中科院分区:
医学2区
文献类型:
--
作者:
Huang TH;Razmovski-Naumovski V;Kota BP;Lin DS;Roufogalis BD

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呼吸系统疾病的研究已达到关键阶段,引入新疗法对于对抗这些使人衰弱的疾病至关重要。随着过氧化物酶体增殖物激活受体的发现及其参与心血管疾病和糖尿病的炎症反应,人们的注意力转向了肺部疾病以及该受体的知识是否可以应用于人类气道的治疗。在本文中,我们探讨了过氧化物酶体增殖物激活受体-γ作为哮喘、慢性阻塞性肺疾病、肺癌和囊性纤维化等肺部疾病的标志物和治疗焦点的前景。预计过氧化物酶体增殖物激活受体-γ配体不仅将提供有用的机制途径信息,而且可能为慢性呼吸系统疾病患者提供新的治疗浪潮。
Research into respiratory diseases has reached a critical stage and the introduction of novel therapies is essential in combating these debilitating conditions. With the discovery of the peroxisome proliferator-activated receptor and its involvement in inflammatory responses of cardiovascular disease and diabetes, attention has turned to lung diseases and whether knowledge of this receptor can be applied to therapy of the human airways. In this article, we explore the prospect of peroxisome proliferator-activated receptor-γ as a marker and treatment focal point of lung diseases such as asthma, chronic obstructive pulmonary disorder, lung cancer and cystic fibrosis. It is anticipated that peroxisome proliferator-activated receptor-γ ligands will provide not only useful mechanistic pathway information but also a possible new wave of therapies for sufferers of chronic respiratory diseases.
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