Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study.
Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study.
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甘油三酯葡萄糖体重指数和血糖水平正常的日本人发生 2 型糖尿病的风险：一项基于人群的纵向队列研究。
DOI：
10.3389/fendo.2022.907973
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发表时间：
2022
影响因子：
5.2
通讯作者：
Wang, Kun
中科院分区：
文献类型：
--
作者：
Song, Bei;Zhao, Xiaofang;Yao, Tianci;Lu, Weilin;Zhang, Hao;Liu, Ting;Liu, Chengyun;Wang, Kun
关键词：
甘油三酯血糖-体重指数(TYG-BMI)已被证明是胰岛素抵抗(IR)的一个现成的、有临床意义的指标。然而，TYG-BMI与2型糖尿病(T2 DM)的相关性仍不确定。本研究旨在研究TYG-BMI与T2 DM的关系，探讨TYG-BMI的预测特征。我们的研究是一项纵向队列研究。8,430名男性和7,034名女性参加了调查和分析。他们都是血糖水平正常的非糖尿病受试者。从1994年到2016年，跟踪调查了13年。将受试者分为四组，每组3866名受试者，使每组的TYG-BMI数值相近。在13年的随访期内，373名受试者被诊断为T2 DM。多变量COX回归分析显示，TYG-BMI是T2 DM发病的独立预测因子。此外，我们的研究确定了四个特定的群体，年轻人(18-44岁)、女性、非高血压人群和非饮酒者患TYG-BMI相关糖尿病的风险显著增加(P-Interaction<；0.05)。预测T2 DM发生的最佳阈值为197.2987(曲线下面积0.7738)。我们的纵向队列研究表明，在血糖水平正常的日本人中，基线TYG-BMI与发生T2 DM的风险呈正相关，并且这种风险在年轻人、女性、非高血压人群和不饮酒者中显著更高。
It has been proved that triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of insulin resistance (IR). Nevertheless, the association between TyG-BMI and incident Type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to study the relationship between TyG-BMI and T2DM and explore the predictive characteristics of TyG-BMI. Our study was conducted as a longitudinal cohort study. 8,430 men and 7,034 women were enrolled and analyzed. They were both non-diabetic subjects with normal glycemic levels. Follow-up lasted for 13 years, from 1994 to 2016. To make the number of TyG-BMI in each group similar, the subjects were divided into four groups with 3866 subjects in each group. During the 13-year follow-up period, 373 subjects were diagnosed with incident T2DM. Our multivariate Cox regression analysis revealed that TyG-BMI was an independent predictor of incident T2DM. In addition, our research identified four specific groups, young people (18-44 years old), women, the non-hypertensive population and non-drinkers were at significantly higher risk of developing TyG-BMI-related diabetes (P-interaction< 0.05). The best threshold TyG-BMI for predicting incident T2DM was 197.2987 (area under the curve 0.7738). Our longitudinal cohort study demonstrated the positive correlation between baseline TyG-BMI and risk of incident T2DM in Japanese with normal glycemic levels, and this risk was significantly higher in the young people, women, the non-hypertensive population and non-drinkers.
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影响因子：
3.9
作者：
Lemmer P;Manka P;Best J;Kahraman A;Kälsch J;Vilchez-Vargas R;Link A;Chiang H;Gerken G;Canbay A;Bechmann LP;Sydor S
通讯作者：
Sydor S
影响因子：
3.7
作者：
Er LK;Wu S;Chou HH;Hsu LA;Teng MS;Sun YC;Ko YL
通讯作者：
Ko YL
影响因子：
4.5
作者：
Li Y;Zheng R;Li J;Feng S;Wang L;Huang Z
通讯作者：
Huang Z
影响因子：
2.1
作者：
Khamseh, Mohammad E.;Malek, Mojtaba;Alaei-Shahmiri, Fariba
通讯作者：
Alaei-Shahmiri, Fariba
影响因子：
9.8
作者：
Buzzetti, Elena;Pinzani, Massimo;Tsochatzis, Emmanuel A.
通讯作者：
Tsochatzis, Emmanuel A.