Carbon Monoxide as an Attenuator of Vasoconstriction in Piglet Cerebral Arterioles1
Carbon Monoxide as an Attenuator of Vasoconstriction in Piglet Cerebral Arterioles1
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一氧化碳作为仔猪脑小动脉血管收缩的减弱剂1
DOI：
--
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发表时间：
2003
影响因子：
3.2
通讯作者：
C. Leffler
中科院分区：
文献类型：
--
作者：
John S. Winestone;C. Bonner;C. Leffler
一氧化碳（CO）是新生儿脑循环的内源性扩张剂。本研究提出了内源性一氧化碳减轻由低碳酸血症、血小板活化因子和血压升高引起的动脉小动脉血管收缩的假设。实验采用麻醉仔猪植入封闭颅窗。局部应用一种金属卟啉血红素加氧酶抑制剂被用来抑制CO的产生。中卟啉铬增加了对低碳酸血症的血管收缩。收缩反应局部刺激，血小板活化因子，也增加了应用铬介卟啉。血红素加氧酶的抑制对血压正常的新生猪（平均动脉压约为70 mmHg）的头小动脉没有收缩作用，但对实验诱导的动脉压升高（平均动脉压大于90 mmHg）的仔猪的头小动脉有收缩作用。事实上，正常血压仔猪的动脉小动脉会短暂扩张至介卟啉铬，而高血压仔猪的动脉小动脉在介卟啉铬治疗10分钟后会逐渐收缩。因此，血红素加氧酶的抑制增强了对几种非常不同的收缩刺激的脑血管收缩。这些数据表明内源性一氧化碳可减弱新生儿脑循环中的血管收缩反应。
Carbon monoxide (CO) is an endogenous dilator in the newborn cerebral circulation. The present study addressed the hypothesis that endogenous CO attenuates pial arteriolar vasoconstriction caused by hypocapnia, platelet activating factor, and elevated blood pressure. Experiments used anesthetized piglets with implanted, closed cranial windows. Topical application of a metal porphyrin inhibitor of heme oxygenase was used to inhibit production of CO. Chromium mesopophyrin increased vasoconstriction in response to hypocapnia. The constrictor response to a topical stimulus, platelet activating factor, was also increased by application of chromium mesoporphyrin. Inhibition of heme oxygenase did not constrict pial arterioles in normotensive newborn pigs (mean arterial pressure of about 70 mmHg), but did constrict pial arterioles of piglets with experimentally induced increases in arterial pressure (mean arterial pressure greater than 90 mmHg). In fact, pial arterioles of normotensive piglets transiently dilated to chromium mesoporphyrin, whereas those of hypertensive piglets progressively constricted during 10 min of chromium mesoporphyrin treatment. Therefore, inhibition of heme oxygenase augments cerebral vasoconstriction in response to several very different constrictor stimuli. These data suggest endogenous CO attenuates vasoconstrictor responses in the newborn cerebral circulation.
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DOI：
10.1152/ajpheart.1997.273.1.h317
发表时间：
1997-07-01
影响因子：
4.8
作者：
Durante, W;Christodoulides, N;Schafer, AI
通讯作者：
Schafer, AI
影响因子：
5
作者：
F. Kozma;Robert A. Johnson;A. Nasjletti
通讯作者：
F. Kozma;Robert A. Johnson;A. Nasjletti
DOI：
10.1152/ajpheart.2000.278.6.h2003
发表时间：
2000-06
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
R. Paternò;D. Heistad;F. Faraci
通讯作者：
R. Paternò;D. Heistad;F. Faraci
影响因子：
15.9
作者：
Morita, T;Kourembanas, S
通讯作者：
Kourembanas, S
影响因子：
15.9
作者：
Kaide, J;Zhang, F;Nasjletti, A
通讯作者：
Nasjletti, A