The Potential Role of Polyamines in Epilepsy and Epilepsy-Related Pathophysiological Changes.
The Potential Role of Polyamines in Epilepsy and Epilepsy-Related Pathophysiological Changes.
复制标题
多胺在癫痫和癫痫相关病理生理变化中的潜在作用
DOI：
10.3390/biom12111596
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发表时间：
2022-10-29
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
癫痫是最常见的神经系统疾病之一，严重影响患者的生活质量。多胺是普遍存在的、带正电荷的脂肪族胺，其以相对高的水平存在，并有助于调节中枢神经系统中细胞膜兴奋性和神经元生理功能的维持。研究表明，癫痫患者和癫痫动物模型中多胺的合成和代谢异常。多胺系统似乎通过多种机制参与癫痫的病理生理过程，例如通过与离子通道相互作用调节离子渗透性，作为氢过氧化物清除剂参与抗氧化，以及通过产生毒性代谢产物诱导细胞损伤。在这篇综述中，我们试图描述多胺和癫痫之间的可能关联，并推测多胺系统是一个潜在的目标，为癫痫治疗的新策略的发展。
Epilepsy is one of the most common neurological disorders and severely impacts the life quality of patients. Polyamines are ubiquitous, positively charged aliphatic amines that are present at a relatively high level and help regulate the maintenance of cell membrane excitability and neuronal physiological functions in the central nervous system. Studies have shown abnormalities in the synthesis and catabolism of polyamines in patients with epilepsy and in animal models of epilepsy. The polyamine system seems to involve in the pathophysiological processes of epilepsy via several mechanisms such as the regulation of ion permeability via interaction with ion channels, involvement in antioxidation as hydroperoxide scavengers, and the induction of cell damage via the production of toxic metabolites. In this review, we try to describe the possible associations between polyamines and epilepsy and speculate that the polyamine system is a potential target for the development of novel strategies for epilepsy treatment.
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影响因子：
5.6
作者：
Anderson LL;Thompson CH;Hawkins NA;Nath RD;Petersohn AA;Rajamani S;Bush WS;Frankel WN;Vanoye CG;Kearney JA;George AL Jr
通讯作者：
George AL Jr
影响因子：
5.5
作者：
Cervetto C;Averna M;Vergani L;Pedrazzi M;Amato S;Pelassa S;Giuliani S;Baldini F;Maura G;Mariottini P;Marcoli M;Cervelli M
通讯作者：
Cervelli M
影响因子：
3.7
作者：
Cervelli M;Bellavia G;D'Amelio M;Cavallucci V;Moreno S;Berger J;Nardacci R;Marcoli M;Maura G;Piacentini M;Amendola R;Cecconi F;Mariottini P
通讯作者：
Mariottini P
影响因子：
3.7
作者：
Kanerva K;Lappalainen J;Mäkitie LT;Virolainen S;Kovanen PT;Andersson LC
通讯作者：
Andersson LC
影响因子：
16.2
作者：
Burda JE;Sofroniew MV
通讯作者：
Sofroniew MV