The Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Allostatic Load Using Bayesian Kernel Machine Regression.
The Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Allostatic Load Using Bayesian Kernel Machine Regression.
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DOI：
10.3390/diseases11010052
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发表时间：
2023-03-22
期刊：
影响因子：
3.7
通讯作者：
Obeng-Gyasi, Emmanuel
中科院分区：
文献类型：
--
作者：
Bashir, Tahir;Obeng-Gyasi, Emmanuel
背景/目的：本研究旨在研究暴露于全氟烷基和多氟烷基物质（PFAS）（一类用于商业和工业应用的有机化合物）对非稳态负荷（AL）（一种慢性应激指标）的影响。PFAS，如全氟癸酸（PFDE）、全氟壬酸（PFNA）、全氟辛烷磺酸（PFOS）、全氟十一烷酸（PFUA）、全氟辛酸（PFOA）和全氟己烷磺酸（PFHS），以及金属，如汞（Hg）、钡（Ba）、镉（Cd）、钴（Co）、铯（Cs）、钼（Mo）、铅（Pb）、锑（Sb）、铊（TI）、钨（W）和铀（U）。本研究旨在探讨PFAS和金属联合暴露对AL的影响，这可能是一种疾病介质。研究方法：2007年至2014年的国家健康和营养检查调查（NHANES）数据用于对20岁及以上的人进行这项研究。使用来自心血管、炎症和代谢系统的10种生物标志物的累积指数来计算10种中的AL。如果总体指数≥ 3，则认为个体长期应激（处于AL状态）。为了评估混合物和结果之间的剂量-反应关系，并限制多重共线性效应和暴露之间的其他潜在相互作用效应，使用贝叶斯核机器回归（BKMR）。结果如下：最显着的正向趋势之间的混合PFAS和金属暴露和AL的联合暴露，以铯，钼，PFHS，PFNA，汞（后验包含概率，PIP = 1，1，0.854，0.824，和0.807，分别）。结论：金属和PFAS的联合暴露增加了处于AL状态的可能性。
Background/Objective: This study aimed to investigate the effect of exposure to per- and polyfluoroalkyl substances (PFAS), a class of organic compounds utilized in commercial and industrial applications, on allostatic load (AL), a measure of chronic stress. PFAS, such as perfluorodecanoic acid (PFDE), perfluorononanoic acid (PFNA), perfluorooctane sulfonic acid (PFOS), perfluoroundecanoic acid (PFUA), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHS), and metals, such as mercury (Hg), barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), thallium (TI), tungsten (W), and uranium (U) were investigated. This research was performed to explore the effects of combined exposure to PFAS and metals on AL, which may be a disease mediator. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2014 were used to conduct this study on persons aged 20 years and older. A cumulative index of 10 biomarkers from the cardiovascular, inflammatory, and metabolic systems was used to calculate AL out of 10. If the overall index was ≥ 3, an individual was considered to be chronically stressed (in a state of AL). In order to assess the dose-response connections between mixtures and outcomes and to limit the effects of multicollinearity and other potential interaction effects between exposures, Bayesian kernel machine regression (BKMR) was used. Results: The most significant positive trend between mixed PFAS and metal exposure and AL was revealed by combined exposure to cesium, molybdenum, PFHS, PFNA, and mercury (posterior inclusion probabilities, PIP = 1, 1, 0.854, 0.824, and 0.807, respectively). Conclusions: Combined exposure to metals and PFAS increases the likelihood of being in a state of AL.
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影响因子：
1.1
作者：
Sakshaug, Joseph W.;Wisniowski, Arkadiusz;Blom, Annelies G.
通讯作者：
Blom, Annelies G.
DOI：
10.3390/ijerph19095455
发表时间：
2022-04-29
影响因子：
--
作者：
Bashir, Tahir;Obeng-Gyasi, Emmanuel
通讯作者：
Obeng-Gyasi, Emmanuel
DOI：
10.1016/j.ssmph.2016.05.003
发表时间：
2016-12
期刊：
SSM - population health
影响因子：
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作者：
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通讯作者：
Kaplan RC
影响因子：
3.9
作者：
Crimmins, EM;Johnston, M;Seeman, T
通讯作者：
Seeman, T
影响因子：
2.5
作者：
Mottaleb, M. Abdul;Petriello, Michael C.;Morris, Andrew J.
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