Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis.
Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis.
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DOI：
10.1016/j.tips.2010.09.004
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发表时间：
2010-12
影响因子：
13.8
通讯作者：
Picciotto MR
中科院分区：
文献类型：
--
作者：
Mineur YS;Picciotto MR
吸烟和抑郁症之间存在着明确的联系，抑郁症患者在吸烟者和戒烟者中的比例过高，戒烟后往往会立即出现抑郁症状。烟草中的尼古丁结合，激活和脱敏烟碱乙酰胆碱受体（nAChR），但目前尚不清楚激活或脱敏是否对尼古丁对抑郁症状的影响更重要。在这篇文章中，我们审查的假设，而不是激活的神经元nAChRs的阻断可能是重要的烟碱类药物对抑郁症状的影响的基础上，临床和临床前研究的烟碱类药物。nAChR的内源性神经递质是乙酰胆碱，尼古丁对抑郁样行为的影响支持胆碱能系统失调可能导致重度抑郁症的病因的观点。因此，通过神经元nAChRs限制乙酰胆碱信号传导的药理学药物可能有希望用于开发新型抗抑郁药物。
There is a well-established connection between smoking and depression, with depressed individuals over-represented among smokers and ex-smokers often experiencing increased depressive symptoms immediately after quitting. Nicotine in tobacco binds, activates and desensitizes nicotinic acetylcholine receptors (nAChRs), but it is not known whether activation or desensitization is more important for nicotine’s effects on depressive symptoms. In this article, we review the hypothesis that blockade rather than activation of neuronal nAChRs might be important for the effects of nicotinic agents on depressive symptoms based on clinical and preclinical studies of nicotinic drugs. The endogenous neurotransmitter for nAChRs is acetylcholine, and the effects of nicotine on depression-like behaviors support the idea that dysregulation of the cholinergic system might contribute to the etiology of major depressive disorder. Thus, pharmacological agents that limit acetylcholine signaling through neuronal nAChRs might be promising for the development of novel antidepressant medications.
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影响因子：
120.7
作者：
GLASSMAN, AH;HELZER, JE;JOHNSON, J
通讯作者：
JOHNSON, J
影响因子：
--
作者：
Brody, Arthur L.;Mandelkern, Mark A.;Mukhin, Alexey G.
通讯作者：
Mukhin, Alexey G.
影响因子：
2.7
作者：
Andreasen, Jesper T.;Redrobe, John P.
通讯作者：
Redrobe, John P.
影响因子：
10.6
作者：
Caldarone, BJ;Harrist, A;Picciotto, MR
通讯作者：
Picciotto, MR
影响因子：
12.7
作者：
HEMENWAY, D;SOLNICK, SJ;COLDITZ, GA
通讯作者：
COLDITZ, GA