Progressive neuropathologic lesions in vitamin E-deficient rhesus monkeys.
Progressive neuropathologic lesions in vitamin E-deficient rhesus monkeys.
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维生素 E 缺乏的恒河猴进行性神经病理学病变。
DOI：
10.1097/00005072-198103000-00008
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发表时间：
1981
影响因子：
3.2
通讯作者：
Chou,AC
中科院分区：
文献类型：
--
作者：
Nelson,JS;Fitch,CD;Fischer,VW;BrounJr,GO;Chou,AC
A consistent group of progressive central and peripheral nervous system lesions developed in seven rhesus monkeys maintained on a vitamin E-deficient diet for 30 to 33 months. These lesions were absent from vitamin E-supplemented monkeys. The principal neuropathologic alteration was loss of sensory axons in the posterior columns, sensory roots, and peripheral nerves. Morphologic and morphometric studies indicated that the distal segments of the axons were affected most severely and large-caliber myelinated fibers are selectively involved. Swollen, dystrophic axons (spheroids) occurred infrequently. Degeneration and phagocytosis of small numbers of neuronal perikarya were observed in the dorsal root ganglia and the anterior horns. The number of affected neurons was not proportional to the number of affected axons. Accumulation of lipopigment was evident in neuronal perikarya and CNS endothelial cells. The nervous system lesions were usually accompanied by a chronic necrotizing myopathy. The neuropathologic lesions in vitamin E-deficient monkeys are compared with those in vitamin E-deficient rats and in humans with low serum vitamin E concentrations. A similar type of sensory axonopathy is associated with chronic deficiency of vitamin E in these three species.
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DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
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作者：
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通讯作者：
Tanzer,ML
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作者：
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影响因子：
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作者：
S. Breul;K. Bradley;A. Hance;M. Schafer;R. Berg;R. Crystal
通讯作者：
R. Crystal
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DOI：
10.1016/s0174-173x(83)80037-5
发表时间：
1983
期刊：
Collagen and related research
影响因子：
--
作者：
A. Palotie
通讯作者：
A. Palotie
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影响因子：
2.9
作者：
Robert S. Bienkowski;Carol J. Engels
通讯作者：
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