Left-sided brain injury associated with more hospital-acquired infections during inpatient rehabilitation.
Left-sided brain injury associated with more hospital-acquired infections during inpatient rehabilitation.
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DOI：
10.1016/j.apmr.2012.10.012
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发表时间：
2013-03
影响因子：
4.3
通讯作者：
Barrett, Anna M.
中科院分区：
文献类型：
--
作者：
Frisina, Pasquale G.;Kutlik, Ann M.;Barrett, Anna M.
验证脑左优势免疫网络（LD-BIN）可能影响脑卒中和创伤性脑损伤（TBI）住院康复期间感染发生的假设。对2009年1月至2010年12月期间的电子病历进行了回顾性分析。所有左侧或右侧卒中或TBI患者均纳入研究。LD-BIN假设通过比较HAI率来检验，HAI率取决于患者是否有左侧或右侧脑病变。一家大型住院康复医院。在患有左侧或右侧脑部病变的中风或TBI患者（N=2236）中，有163名患者被确定患有HAI。不适用因HAI的频率在163例确诊为卒中或TBI的HAI患者中，卡方分析显示左侧脑损伤患者（n=98; 60.1%）的HAI比例显著高于右侧脑损伤患者（n=65; 39.9%）（χ2=6.68，P<0.01）。这些影响不能归因于临床或人口统计学因素。我们的研究结果是一致的假设，即LD-BIN可能介导的脆弱性，在中风或创伤性脑损伤患者康复感染。进一步的转化研究调查基于脑损伤位置管理患者的新方法，并通过行为和生理干预调节LD-BIN，可能会导致基于神经科学的方法来提高脑损伤患者的感染抵抗力。
To test the hypothesis that a left-dominant brain immune network (LD-BIN) might affect the occurrence of infection during inpatient rehabilitation of stroke and traumatic brain injury (TBI). A retrospective analysis was performed on electronic medical records between January 2009 and December 2010. All patients with left-or right-sided stroke or TBI were included into the study. The LD-BIN hypothesis was tested by comparing HAI rates depending on whether patients had left- or right-sided brain lesions. A large inpatient rehabilitation hospital. Among the patients (N=2236) with stroke or TBI who had either a left- or right-sided brain lesion, 163 patients were identified with HAIs. Not applicable. Frequency of HAIs. In the 163 patients identified with HAIs with a diagnosis of stroke or TBI, chi-square analysis revealed a significantly higher proportion of HAIs among patients with left-sided (n=98; 60.1%) relative to right-sided (n=65; 39.9%) brain injuries (χ2=6.68, P<.01). These effects could not be attributed to either clinical or demographic factors. Our findings are consistent with the hypothesis that an LD-BIN may mediate vulnerability to infection during rehabilitation of patients with stroke or TBI. Further translational research investigating novel means of managing patients based on brain lesion location, and modulating the LD-BIN via behavioral and physiologic interventions, may result in neuroscience-based methods to improve infection resistance in brain-injured patients.
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影响因子：
64.8
作者：
Brandl, Katharina;Plitas, George;Mihu, Coralia N.;Ubeda, Carles;Jia, Ting;Fleisher, Martin;Schnabl, Bernd;DeMatteo, Ronald P.;Pamer, Eric G.
通讯作者：
Pamer, Eric G.
影响因子：
9.9
作者：
Koch, G.;Bonni, S.;Caltagirone, C.
通讯作者：
Caltagirone, C.
影响因子：
2.2
作者：
Galletta EE;Rao PR;Barrett AM
通讯作者：
Barrett AM
影响因子：
3.1
作者：
Jarchum, Irene;Liu, Mingyu;Pamer, Eric G.
通讯作者：
Pamer, Eric G.
DOI：
10.1111/j.1749-6632.1988.tb27188.x
发表时间：
1988-01-01
影响因子：
5.2
作者：
Czlonkowska, A;Korlak, J;Kuczynska, A
通讯作者：
Kuczynska, A