Predominant functional roles for thromboxane A2 and prostaglandin E2 during late nephrotoxic serum glomerulonephritis in the rat.
Predominant functional roles for thromboxane A2 and prostaglandin E2 during late nephrotoxic serum glomerulonephritis in the rat.
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血栓素 A2 和前列腺素 E2 在大鼠晚期肾毒性血清肾小球肾炎期间的主要功能作用。
DOI：
10.1172/jci114661
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Badr,KF
中科院分区：
文献类型：
--
作者：
Takahashi,K;Schreiner,GF;Yamashita,K;Christman,BW;Blair,I;Badr,KF
虽然对急性肾毒性血清（NTS）诱导的肾小球损伤了解很多，但更相关的慢性自体阶段的肾小球动力学和病理生理介质仍然定义不清。在注射兔血清（n = 6）、NTS（不存在（n = 6）或存在环加氧酶抑制剂布洛芬（n = 6）或血栓素A2（TxA 2）受体拮抗剂L-670，596（n = 5））后14天，在大鼠中进行研究。在所有经NTS处理的大鼠中均观察到同等强度的系膜巨噬细胞/单核细胞浸润。与对照组相比，肾炎肾中前列腺素（PG）E2、PGF 2a和TxA 2的肾小球生成率显著增加。NTS后2 wk，肾小球血浆流速（SNPF）增加，滤过压失衡，跨毛细血管净液压差（Δ P）增大。然而，肾小球滤过率（GFR）降低，这是由于肾小球毛细血管超滤系数（Kf）显著下降。环氧合酶抑制导致肾小球类花生酸生成率正常化，蛋白尿改善，传入血管收缩，SNPF，δ P，Kf和GFR正常化。TxA 2的选择性拮抗作用也导致Kf的保留，但对SNPF没有影响，从而导致GFR值升高。因此，与花生四烯酸脂氧合酶产物在早期异源阶段的病理生理作用相反，PG介导的血管舒张和TxA 2诱导的Kf和GFR降低是自体系膜增生性肾小球肾炎期间肾小球功能变化的基础。图片
While much is known regarding acute nephrotoxic serum (NTS)-induced glomerular injury, the glomerular dynamics and pathophysiologic mediators of the more relevant chronic autologous phase remain poorly defined. Studies were performed in rats 14 d after injection of rabbit serum (n = 6), NTS in the absence (n = 6), or presence, of a cyclooxygenase inhibitor, ibuprofen (n = 6) or a thromboxane A2 (TxA2) receptor antagonist, L-670,596 (n = 5). A mesangial macrophage/monocyte infiltrate was noted with equal intensity in all NTS-treated rats. Glomerular generation rates of prostaglandin (PG) E2, PGF2a, and TxA2 in nephritic kidneys were dramatically increased as compared to controls. 2 wk after NTS, there was an increase in glomerular plasma flow rate (SNPF), attainment of filtration pressure disequilibrium, and augmentation of net transcapillary hydraulic pressure difference (delta P). Glomerular filtration rate (GFR), however, was reduced, due to a marked fall in the glomerular capillary ultrafiltration coefficient (Kf). Cyclooxygenase inhibition resulted in normalization of glomerular eicosanoid generation rates, amelioration of proteinuria, afferent vasoconstriction, and normalization of SNPF, delta P, Kf, and GFR. Selective antagonism of TxA2 also led to preservation of Kf, but was without effect on SNPF, thereby leading to elevated values for GFR. Thus, in contrast to the pathophysiologic role of arachidonate-lipoxygenase products in the early heterologous phase, PG-mediated vasodilatation and TxA2-induced reductions in Kf and GFR underlie glomerular functional changes during autologous mesangioproliferative glomerulonephritis.Images
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大鼠肾小球超滤的动力学。
影响因子：
15.9
作者：
W. Deen;J. L. Troy;C. Robertson;B. Brenner
通讯作者：
B. Brenner
人狼疮性肾炎的肾小球毛细血管壁功能。
DOI：
10.1152/ajprenal.1984.246.5.f580
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
Friedman,S;Strober,S;Field,EH;Silverman,E;Myers,BD
通讯作者：
Myers,BD
大鼠肾小球免疫损伤：血管紧张素II和α-肾上腺素能抑制剂的影响
DOI：
--
发表时间：
1981
期刊：
影响因子：
--
作者：
R. Blantz;B. J. Tucker;L. Gushwa;Örjan W. Peterson;C. Wilson
通讯作者：
C. Wilson
大鼠实验性肾小球肾炎肾小球滤过的决定因素。
影响因子：
15.9
作者：
D. A. Maddox;C. Bennett;W. Deen;R. Glassock;D. Knutson;T. Daugharty;B. Brenner
通讯作者：
B. Brenner
特定白三烯 D4 受体拮抗剂对大鼠肾毒性血清肾炎期间肾小球毛细血管超滤系数的保护。
DOI：
10.1172/jci113509
发表时间：
1988
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Badr,KF;Schreiner,GF;Wasserman,M;Ichikawa,I
通讯作者：
Ichikawa,I