Associations Among Menstrual Cycle Length, Coronavirus Disease 2019 (COVID-19), and Vaccination.
Associations Among Menstrual Cycle Length, Coronavirus Disease 2019 (COVID-19), and Vaccination.
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DOI：
10.1097/aog.0000000000005343
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发表时间：
2024-01-01
影响因子：
7.2
通讯作者：
中科院分区：
文献类型：
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作者：
经历冠状病毒病(新冠肺炎)与月经周期长度的微小变化有关，这与接种新冠肺炎疫苗类似。评估冠状病毒病2019年(新冠肺炎)是否与月经周期长度变化有关，如果是，与正在接种疫苗或没有事件的患者(对照组)进行比较。我们进行了回溯性队列分析，分析了来自周期跟踪应用程序用户的前瞻性跟踪周期长度数据，这些用户也回答了一项关于新冠肺炎症状和疫苗接种的调查。我们将样本限制在16-45岁的用户，他们的周期长度正常(24-38天)，并在新冠肺炎症状或疫苗接种前后的五个周期内定期跟踪行为，或者对于那些没有经历任何事件的人(对照组)。我们计算了从事件(周期4)和事件(周期5)周期到事件(周期4)和事件后(周期5)周期的连续三个周期(接种疫苗、疾病或两者都不；周期1-3)的用户内周期长度(天数)的变化。我们使用混合效应模型来估计年龄和国家调整后的不同群体之间周期长度变化的差异。我们包括来自110个国家的6,514名用户，代表32,570个周期(新冠肺炎症状：1,450；新冠肺炎疫苗接种：4,643；对照：421)。与他们的三个赛前周期(95%CI 0.86-2.04)相比，新冠肺炎队列在第4周期(新冠肺炎)的周期长度调整后增加了1.45天。与事件前的平均值(95%CI为0.60-1.69)相比，接种组在第4周期(新冠肺炎疫苗)中的周期长度调整后增加了1.14天。对照组(既没有接种疫苗也没有疾病)在类似的时间段经历了0.68d的下降(95%CI−1.18至−0.19)。事后测试显示，新冠肺炎和疫苗接种队列之间的变化幅度没有显著差异。在两个队列中，周期长度的变化在事件后周期中消失。与接种新冠肺炎疫苗类似，体验新冠肺炎与周期长度的微小变化有关。这些变化在下一个周期内很快就会解决。
Experiencing coronavirus disease (COVID-19) is associated with a small change in menstrual cycle length that is similar to COVID-19 vaccination. To assess whether coronavirus disease 2019 (COVID-19) is associated with menstrual cycle length changes and, if so, how that compares with those undergoing vaccination or no event (control). We conducted a retrospective cohort analysis in which we analyzed prospectively tracked cycle-length data from users of a period tracker application who also responded to a survey regarding COVID-19 symptoms and vaccination. We restricted our sample to users aged 16–45 years, with normal cycle lengths (24–38 days) and regular tracking behavior during the five cycles around COVID-19 symptoms or vaccination or a similar time period for those experiencing no event (control group). We calculated the within-user change in cycle length (days) from the three consecutive cycles preevent average (either vaccination, disease, or neither; cycles 1–3) to the event (cycle 4) and postevent (cycle 5) cycles. We used mixed-effects models to estimate the age- and country-adjusted difference in change in cycle length across the groups. We included 6,514 users from 110 countries representing 32,570 cycles (COVID-19 symptoms: 1,450; COVID-19 vaccination: 4,643; control: 421). The COVID-19 cohort experienced a 1.45-day adjusted increase in cycle length during cycle 4 (COVID-19) compared with their three preevent cycles (95% CI 0.86–2.04). The vaccinated group experienced a 1.14-day adjusted increase in cycle length during cycle 4 (COVID-19 vaccine) compared with their preevent average (95% CI 0.60–1.69). The control group (neither vaccine nor disease) experienced a 0.68-day decrease (95% CI −1.18 to −0.19) in a similar time period. Post hoc tests showed no significant differences in the magnitude of changes between the COVID-19 and vaccination cohorts. In both cohorts, cycle length changes disappeared in the postevent cycle. Experiencing COVID-19 is associated with a small change in cycle length similar to COVID-19 vaccination. These changes resolve quickly within the next cycle.
影响因子：
2.1
作者：
Gibbons C;Hussain M;O'Keeffe DT;Simpkin AJ
通讯作者：
Simpkin AJ