The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration.
The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration.
复制标题
鞘脂和胰岛素样生长因子信号传导之间的串扰：衰老和神经变性的重要性。
DOI：
10.1007/s12035-018-1286-3
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发表时间：
2019-05
影响因子：
5.1
通讯作者：
Strosznajder RP
中科院分区：
文献类型：
--
作者：
Jęśko H;Stępień A;Lukiw WJ;Strosznajder RP
生物活性鞘脂：鞘氨醇、鞘氨醇-1-磷酸（S1 P）、神经酰胺和神经酰胺-1-磷酸（C1 P）越来越多地涉及细胞存活、增殖、分化和神经系统中应激反应的多个方面。密切相关的鞘脂物种在细胞生存/死亡信号传导中的相反作用反映在严格控制的鞘脂变阻器的概念中。衰老对鞘脂代谢、干扰信号传导途径和脂膜性质具有复杂的影响。抗应激相关鞘脂的代谢特征与人类寿命相关。此外，越来越多的证据表明鞘脂信号传导与胰岛素样生长因子I（IGF-I）-Akt-mTOR通路（IIS）之间存在广泛的联系，其参与衰老过程和寿命的调节。IIS整合了广泛的代谢信号，与p53、核因子κB（NF-κB）或活性氧（ROS）进行交叉对话，并影响基因表达以塑造细胞代谢特征和应激抗性。鞘脂和IIS信号之间的多重联系表明这些化合物可能参与衰老过程本身，这为大多数神经退行性疾病创造了脆弱的背景。
Bioactive sphingolipids: sphingosine, sphingosine-1-phosphate (S1P), ceramide, and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation, differentiation, and in multiple aspects of stress response in the nervous system. The opposite roles of closely related sphingolipid species in cell survival/death signaling is reflected in the concept of tightly controlled sphingolipid rheostat. Aging has a complex influence on sphingolipid metabolism, disturbing signaling pathways and the properties of lipid membranes. A metabolic signature of stress resistance-associated sphingolipids correlates with longevity in humans. Moreover, accumulating evidence suggests extensive links between sphingolipid signaling and the insulin-like growth factor I (IGF-I)-Akt-mTOR pathway (IIS), which is involved in the modulation of aging process and longevity. IIS integrates a wide array of metabolic signals, cross-talks with p53, nuclear factor κB (NF-κB), or reactive oxygen species (ROS) and influences gene expression to shape the cellular metabolic profile and stress resistance. The multiple connections between sphingolipids and IIS signaling suggest possible engagement of these compounds in the aging process itself, which creates a vulnerable background for the majority of neurodegenerative disorders.
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影响因子：
3.7
作者：
Arana, Lide;Gangoiti, Patricia;Gomez-Munoz, Antonio
通讯作者：
Gomez-Munoz, Antonio
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影响因子：
3.7
作者：
Bokov AF;Garg N;Ikeno Y;Thakur S;Musi N;DeFronzo RA;Zhang N;Erickson RC;Gelfond J;Hubbard GB;Adamo ML;Richardson A
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3.7
作者：
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影响因子：
7.8
作者：
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通讯作者：
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