Neonatal estrogen affects preoptic/anterior hypothalamic LHRH differently in adult male and female rats.
Neonatal estrogen affects preoptic/anterior hypothalamic LHRH differently in adult male and female rats.
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新生雌激素对成年雄性和雌性大鼠视前/下丘脑前部 LHRH 的影响不同。
DOI：
10.1159/000123868
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发表时间：
1984
影响因子：
4.1
通讯作者：
Leeman,SE
中科院分区：
文献类型：
--
作者：
Elkind-Hirsch,K;King,JC;Gerall,AA;Leeman,SE
当雌激素在关键的围产期使用时，它会永久性地改变男性和女性的生殖功能。本研究评价了在此期间给予外源性雌激素对成年雌雄大鼠下丘脑LHRH含量和促性腺激素分泌的影响。用放射免疫法测定了新生雌性大鼠(产后第2天1 mg)和正常雌雄大鼠动情周期视前-下丘脑前部(PO/AH)和下丘脑中段(MH)的LHRH含量。雌激素化新生大鼠PO/AH区LHRH含量显着高于雌激素化雄鼠，而对照组雌雄大鼠PO/AH区LHRH含量无明显差异。新生鼠给予雌激素后，雌鼠MH的LHRH含量增加，雄鼠的LHRH含量降低，与PO/AH相同，但在MH中这些差异不显著，且无统计学意义。在发情前期的对照周期雌性动物中，血清黄体生成素水平的显著升高可被新生儿雌激素治疗所消除。暴露于新生儿雌激素可降低男性的FSH浓度。这些数据与下丘脑-垂体系统在性别分化期间受到雌激素循环的影响这一概念是一致的。LHRH的合成和释放似乎直接受到新生儿雌激素的影响。新生雌激素治疗对PO/AH和MH区的影响可能涉及两种不同类型的发育中的LHRH神经元的变化，这些神经元调节成年大鼠促性腺激素的分泌。
When administered during the critical perinatal period, estrogen permanently modifies both male and female reproductive function. This study evaluated the influence of exogenous estrogen administered during this time on the hypothalamic LHRH content and on gonadotropin secretion in adult male and female rats. LHRH content in the preoptic-anterior hypothalamic (PO/AH) and midhypothalamic (MH) areas of neonatally estrogenized rats (1 mg on postpartum day 2) and of control male and female rats during the estrous cycle was determined by radioimmunoassay between 80 and 90 days of age. LHRH content was significantly greater in the PO/AH of neonatally estrogenized females than in estrogenized males whereas no differences in LHRH content of the PO/AH existed between control male and female rats. Neonatal administration of estrogen resulted in increased LHRH content in the MH of female rats and decreased LHRH content in male rats, as in the PO/AH; however, these differences were less marked in the MH and not statistically significant. The marked increase in serum LH concentration present in control cycling females in proestrus was abolished by neonatal estrogen treatment. Exposure to neonatal estrogen reduced FSH concentrations in males. The data are consistent with the concept that the hypothalamic-pituitary system is modified by estrogen circulating during the period of sexual differentiation. LHRH synthesis and release appear to be directly modified by neonatal estrogen. The effects of neonatal estrogen treatment in the PO/AH and MH areas may possibly involve two disparate types of alterations of developing LHRH neurons which modulate gonadotropin secretion in the adult rat.
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影响因子：
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作者：
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DOI：
10.1016/s0047-0740(85)80002-4
发表时间：
1985
期刊：
International journal of nuclear medicine and biology
影响因子：
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作者：
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DOI：
10.1016/0883-2889(86)90080-8
发表时间：
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期刊：
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes
影响因子：
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作者：
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影响因子：
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作者：
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